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张 静1 丁 洁2 张翼宙1.浙派中医下多囊卵巢综合征中医证素特征与月经异常情况及性激素水平相关性分析[J].中国现代医生,2021,59(30):140-142+146
浙派中医下多囊卵巢综合征中医证素特征与月经异常情况及性激素水平相关性分析
Correlation analysis of the characteristics of polycystic ovary syndrome TCM syndrome elements in Zhejiang school TCM syndrome with abnormal menstruation and sex hormone levels
  
DOI:
中文关键词:  浙派中医  多囊卵巢综合征  中医证素特征  月经异常情况  性激素水平
英文关键词:Zhejiang School of Traditional Chinese Medicine  Polycystic ovary syndrome  Characteristics of TCM syndrome elements  Menstrual abnormalities  Sex hormones level
基金项目:浙江省中医药科学研究基金项目(A 类)(2018Z A030)
作者单位
张 静1 丁 洁2 张翼宙1 1.浙江中医药大学浙江杭州 3140012.南京医科大学附属常州第二人民医院肿瘤中心江苏常州 213164 
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中文摘要:
      目的 分析浙派中医下多囊卵巢综合征中医证素特征与月经异常情况及性激素水平相关性。方法 随机选取2015 年1 月至2019 年5 月我院多囊卵巢综合征患者300 例,依据《中医体质分类与判定》标准,并将其与舌象、脉象有机结合起来分析中医证素特征,治疗前月经周期第2~4 天早晨抽取所有患者的5 mL 空腹静脉血,对其外周血血清睾酮(T)、孕酮(P)、雌二醇(E2)、促黄体生成素(LH)、卵泡雌激素(FSH)、泌乳素(PRL)水平进行测定。然后分析其与月经异常情况及性激素水平相关性。结果 痰湿质、气郁质、湿热质患者的LH/FSH 均显著高于阳虚质、气虚质、平和质、淤血质、阴虚质,差异有统计学意义(P<0.05);气郁质患者的血清E2、PRL 水平显著高于痰湿质、湿热质、阳虚质、气虚质、平和质、淤血质、阴虚质,差异有统计学意义(P<0.05);湿热质患者的血清T 水平显著高于痰湿质、气郁质、阳虚质、气虚质、平和质、淤血质、阴虚质,差异有统计学意义(P<0.05)。中医证素特征与性激素水平呈正相关(r=0.563,P<0.05)。结论 浙派中医下多囊卵巢综合征中医证素特征与月经异常情况无关,与性激素水平相关。
英文摘要:
      Objective To analyze the correlation between polycystic ovary syndrome TCM syndrome element characteristics in Zhejiang school TCM syndrome and abnormal menstruation and sex hormones level.Methods A total of 300 patients with the polycystic ovarian syndrome in our hospital from January 2015 to May 2019 were randomly selected.According to the criteria of "Classification and Judgment of TCM Constitution" organically combined with tongue and pulse,the characteristics of TCM syndrome elements were analyzed.5 mL fasting venous blood was drawn from all patients in the morning of the second to the fourth day of the menstrual cycle before treatment.The peripheral blood serum testosterone(T),progesterone(P),estradiol(E2),luteinizing hormone(LH),follicular estrogen(FSH),and prolactin(PRL)levels of the patients were measured.Then the correlation between TCM syndrome element characteristics with menstrual abnormalities and sex hormones level was analyzed.Results The LH/FSH in patients with phlegm-dampness,qi stagnation,and damp-heat were significantly higher than those in patients with yang deficiency,qi deficiency,calmness,blood stasis,and yin deficiency,and the differences were statistically significant(P<0.05).The serum E2 and PRL levels in patients with qi stagnation were significantly higher than those in patients with phlegm-dampness,damp-heat,yang deficiency,qi deficiency,calmness,blood stasis,and yin deficiency,and the differences were statistically significant(P<0.05).The serum T levels in patients with damp-heat were significantly higher than those in patients with phlegm-dampness,qi stagnation,yang deficiency,qi deficiency,calmness,blood stasis,and yin deficiency,and the differences were statistically significant(P<0.05).TCM syndrome element characteristics had positive correlation with sex hormones level(r=0.563,P<0.05).Conclusion The characteristics of polycystic ovary syndrome TCM syndrome elements in Zhejiang School of Traditional Chinese Medicine are not related to abnormal menstruation but related to the level of sex hormones.
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