| 魏香兰.2型肥胖糖尿病患者应用胰岛素联合SGLT2抑制剂疗效和安全性研究[J].中国现代医生,2021,59(30):111-114 |
| 2型肥胖糖尿病患者应用胰岛素联合SGLT2抑制剂疗效和安全性研究 |
| Study on the efficacy and safety of insulin combined with SGLT2 inhibitors in obese patients with type 2 diabetes mellitus |
| |
| DOI： |
| 中文关键词: 2 型肥胖糖尿病 胰岛素 SGLT2 抑制剂 安全性 |
| 英文关键词:Type 2 diabetes mellitus with obesity Insulin SGLT2 inhibitor Safety |
| 基金项目: |
|
| 摘要点击次数: 2163 |
| 全文下载次数: 8136 |
| 中文摘要: |
| 目的 观察胰岛素联合SGLT2 抑制剂对2 型肥胖糖尿病患者疗效及安全性的影响。方法 纳入2019 年6月至2020 年6 月我院收治的2 型肥胖糖尿病患者共120 例，将所有研究对象随机分为联合组与单一组，每组各60例。单一组给予常规胰岛素治疗，联合组在单一组基础上给予SGLT2 抑制剂，观察两组疗效、肥胖指标、血糖水平及安全性情况。结果 联合组临床总有效率为93.33%，高于单一组的71.67%，差异有统计学意义（P＜0.05）。组内比较，两组BMI、WC 指数、FBG、2 hPG、HbA1c 水平均低于治疗前（P＜0.05）；组间比较，联合组BMI、WC 指数、血糖各指标水平均低于单一组（P＜0.05）。联合组不良反应总发生率为5.00%，低于单一组的30.00%，差异有统计学意义（P＜0.05）。结论 胰岛素联合SGLT2 抑制剂治疗2 型肥胖糖尿病的疗效显著，可降低患者体质量指数、腰围及血糖水平，且安全性较高，值得临床广泛推广并应用。 |
| 英文摘要: |
| Objective To observe the effect of insulin combined with SGLT2 inhibitor on the efficacy and safety in treating obese patients with type 2 diabetes mellitus.Methods A total of 120 obese patients with type 2 diabetes mellitus who were admitted to our hospital from June 2019 to June 2020 were enrolled.All subjects were randomly divided into the combination group and the single-therapy group，with 60 cases in each group.The single-therapy group was given conventional insulin treatment，while the combination group was given SGLT2 inhibitors on the basis of the same treatment as the single-therapy group.The efficacy，obesity indicators，blood glucose levels and safety of the two groups were observed.Results The total effective rate of clinical treatment in the combination group was 93.33%，wihch was higher than that of 71.67% in the single-therapy group，with statistically significant difference (P＜0.05).According to the comparison within the groups，the BMI，WC index，FBG，2 hPG and HbA1c levels of the two groups after treatment were lower than those before treatment(P＜0.05).According to the comparison between groups，the levels of BMI，WC index，and blood glucose in the combination group were lower than those in the single-therapy group (P＜0.05).The total incidence of adverse reactions in the combination group was 5.00%，which was lower than that of 30.00% in the single-therapy group，with statistically significant difference (P＜0.05).Conclusion Insulin combined with SGLT2 inhi bitors has a significant effect on the treatment of obese patients with type 2 diabetes mellitus.It can reduce the patient's body mass index，waist circumference and blood glucose level，with higher safety.It is worthy of widespread promotion and application in clinical practice. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
