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蒋大明.rt-PA静脉溶栓联合丁苯酞静脉注射治疗急性脑梗死临床研究[J].中国现代医生,2021,59(30):100-102
rt-PA静脉溶栓联合丁苯酞静脉注射治疗急性脑梗死临床研究
Clinical study of intravenous thrombolysis with rt-PA combined with intravenous butylphthalide in treatment of acute cerebral infarction
  
DOI:
中文关键词:  rt-PA  丁苯酞  急性脑梗死  静脉溶栓  临床疗效
英文关键词:rt-PA  Butylphthalide  Acute cerebral infarction  Intravenous thrombolysis  Clinical efficacy
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作者单位
蒋大明 江苏省连云港市东方医院急诊科江苏连云港 222042 
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中文摘要:
      目的 探讨急性脑梗死应用rt-PA 静脉溶栓联合丁苯酞静脉注射治疗的临床疗效。方法 将2018 年1 月至2020 年6 月我院收治的60 例急性脑梗死患者通过计算机随机填表法分为研究组与对照组,两组各纳入30例,两组患者入院后立即展开吸氧、抗血小板及输液等常规治疗,给予对照组患者实施rt-PA 静脉溶栓治疗,研究组在对照组基础上联合丁苯酞静脉注射,对比两组患者临床疗效、NHISS 评分、Barthel 指数、血清炎症指标及不良反应。结果 研究组临床总有效率明显高于对照组,NHISS 评分低于对照组,Barthel 指数高于对照组,hs-CRP、TNF-α 及IL-6 水平均低于对照组,差异有统计学意义(P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 急性脑梗死应用rt-PA 静脉溶栓联合丁苯酞静脉注射治疗效果显著,能有效降低血清炎症水平,改善神经功能,提高生活活动能力,值得应用推广。
英文摘要:
      Objective To investigate the clinical effect of intravenous thrombolysis with rt-PA combined with intravenous butylphthalide in the treatment of acute cerebral infarction.Methods A total of 60 patients with acute cerebral infarction who were admitted to our hospital from January 2018 to June 2020 were randomly divided into the study group and the control group by the computer random form filling method,with 30 patients in each group.Patients in the two groups were immediately treated with oxygen inhalation,antiplatelet and infusion after admission.Patients in the control group were treated with?intravenous thrombolysis with rt-PA,and patients in the study group were combined with intravenous butylphthalide on the basis of the control group.The clinical efficacy,NHISS scores,Barthel indexes,serum inflammatory indexes and adverse reactions in the two groups were compared.Results The clinical total effective rate of the study group was significantly higher than that of the control group;the NHISS score of the study group was lower than that of the control group;the Barthel index of the study group was higher than that of the control group;the level of hs-CRP,TNF-α and IL-6 of the study group were lower than that of the control group;the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Intravenous thrombolysis with rt-PA combined with intravenous butylphthalide in the treatment of acute cerebral infarction has a significant therapeutic effect,which can effectively reduce the serum inflammatory level,improve neurological function,and enhance the ability of living activities.Therefore,it is worthy of application and promotion.
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