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巩 伟 李泽宇 邹 益 王 朋 王 红▲.PLR、PDW联合BISAP评分对急性胰腺炎严重程度的预测价值[J].中国现代医生,2021,59(30):62-65+69+封三
PLR、PDW联合BISAP评分对急性胰腺炎严重程度的预测价值
The predictive value of PLR,PDW combined with the BISAP score for the severity of acute pancreatitis
  
DOI:
中文关键词:  急性胰腺炎  血小板/淋巴细胞比值  血小板分布宽度  BISAP 评分
英文关键词:Acute pancreatitis  Platelet/lymphocyte ratio  Platelet distribution width  BISAP score
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作者单位
巩 伟 李泽宇 邹 益 王 朋 王 红▲ 郑州大学第一附属医院消化内科河南郑州 450000 
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中文摘要:
      目的 探讨不同程度急性胰腺炎(AP)患者血小板与淋巴细胞比值(PLR)、血小板分布宽度(PDW)水平变化及联合BISAP 评分在诊断疾病严重程度中的价值。方法 回顾性分析2018 年1 月至2019 年12 月期间在我院住院的急性胰腺炎患者,分为轻度胰腺炎(MAP)、中度胰腺炎(MSAP)、重度胰腺炎(SAP)三组,并收集24 h 内检测的外周血血细胞计数及基本生命体征等临床资料,计算PLR、PDW 及BISAP 评分,比较各组间的差异。采用受试者工作特征曲线(ROC 曲线)对诊断效能进行评估。结果 共有120 例患者纳入本次研究,SAP 组患者PLR、PDW 及BISAP 评分的水平均高于MSAP 组、MAP 组[PLR:(152.57±62.23)vs.(227.80±108.65)vs.(315.83±281.50);PDW:(16.58±1.14)% vs.(17.19±0.81)% vs.(17.26±0.65)%;BISAP 评分:(1.38±0.49)分vs.(2.27±0.81)分vs.(3.12±0.98)分],差异均有统计学意义(P<0.05)。Pearson 相关性分析显示,在疾病严重程度方面,PLR、PDW 及BISAP 评分与急性胰腺炎的严重程度均呈正相关,差异有统计学意义(P<0.05)。ROC 曲线分析显示,PLR、PDW、BISAP 评分及三者联合的曲线下面积分别为0.673、0.653、0.842 和0.885。三者联合诊断的价值高于单一指标的诊断价值。PLR+PDW+BISAP 评分的cut-off 值为0.1181 时灵敏度为0.971,特异度为0.663,95%CI 0.825~0.945。结论PLR、PDW 可反映疾病的严重程度,PLR、PDW、BISAP 评分联合使用对急性重症胰腺炎有重要的临床诊断价值。
英文摘要:
      Objective To explore the value of platelet-to-lymphocyte ratio (PLR) and platelet distribution width (PDW)levels and the combined BISAP score in the diagnosis of disease severity in patients with different degrees of acute pancreatitis (AP).Methods The acute pancreatitis patients hospitalized in our hospital from January 2018 to December 2019 were retrospectively analyzed.They were divided into mild acute pancreatitis group (MAP),moderately severe acute pancreatitis group (MSAP),and severe acute pancreatitis group (SAP).The peripheral blood cell count detected within 24 hours and basic vital signs were collected.The PLR,PDW,and BISAP scores were calculated.The differences between the groups were compared.The receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy.Results A total of 120 patients were included in this study.The scores of PLR,PDW and BISAP in the SAP group were higher than those in the MSAP and MAP groups [PLR:(152.57±62.23) vs. (227.80±108.65) vs. (315.83±281.50);PDW:(16.58±1.14)% vs. (17.19±0.81)% vs. (17.26±0.65)%];BISAP score:(1.38±0.49)points vs. (2.27±0.81)points vs. (3.12±0.98)points],and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that in terms of disease severity,PLR,PDW and BISAP scores were positively correlated with the severity of acute pancreatitis,and the difference was statistically significant(P<0.05). ROC curve analysis showed that the area under the curve of PLR,PDW,BISAP score,and the combination of the above three were 0.673,0.653,0.842 and 0.885,respectively.The value of the combined diagnosis of the above three was higher than that of a single index.When the cut-off value of PLR+PDW+BISAP score was 0.1181,the sensitivity was 0.971,and the specificity was 0.663 95%CI 0.825-0.945.Conclusion PLR and PDW can reflect the severity of the disease.The combined use of PLR,PDW and BISAP scores has important clinical diagnostic value for severe acute pancreatitis.
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