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林金丁 曾荣东 汤海峰 许志通.D-二聚体、降钙素原在判断化脓性关节炎病情中的价值[J].中国现代医生,2021,59(27):106-109
D-二聚体、降钙素原在判断化脓性关节炎病情中的价值
The value of D-dimer and procalcitonin in determining the condition of septic arthritis
  
DOI:
中文关键词:  D-二聚体  降钙素原  化脓性关节炎  脓毒血症
英文关键词:D-dimer  Procalcitonin  Septic arthritis  Sepsis
基金项目:福建省泉州市科技计划项目(2018Z051)
作者单位
林金丁 曾荣东 汤海峰 许志通 福建医科大学附属泉州第一医院骨科福建泉州 362000 
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中文摘要:
      目的 探讨D-二聚体、降钙素原在判断化脓性关节炎感染严重程度的临床意义及价值。方法 回顾性分析2018 年1 月至2020 年6 月在我院治疗的71例的化脓性关节炎患者的资料。根据血培养结果判断是否合并脓毒血症,分为普通感染组和脓毒血症组。比较两组患者D-二聚体、降钙素原的区别,分析D-二聚体、降钙素原在判断化脓性关节炎病情中的临床意义。结果 化脓性关节炎合并脓毒血症组的降钙素原为(5.06±1.30)ng/mL,普通感染组的降钙素原为(2.62±1.51)ng/mL,差异有统计学意义(P<0.05)。脓毒血症组的D-二聚体为(2.21±0.85)mg/L,普通感染组的D-二聚体为(1.03±0.66)mg/L,两组比较差异有统计学意义(P<0.05)。D-二聚体判断化脓性关节炎合并脓毒血症的ROC 曲线下面积为0.814(95%CI:0.702~0.927),最佳的临界阈值为2.20 mg/L。降钙素原判断化脓性关节炎合并脓毒血症的ROC 曲线下面积为0.891(95%CI:0.809~0.973),最佳的临界阈值为3.85 ng/mL。结论 D-二聚体、降钙素原可作为辅助判断化脓性关节炎病情的参考指标。
英文摘要:
      Objective To explore the clinical significance and value of D-dimer and procalcitonin in determining the severity of septic arthritis infection.Methods The data of 71 patients with septic arthritis treated in our hospital from January 2018 to June 2020 were retrospectively analyzed.These patients were judged whether also had sepsis based on the blood culture results,and divided into the general infection group and the sepsis group.The differences of D-dimer and procalcitonin between the two groups were compared,and the clinical significance of D-dimer and procalcitonin in determining the condition of septic arthritis were analyzed.Results The procalcitonin was(5.06±1.30)ng/mL in the sepsis group and(2.62±1.51)ng/mL in the general infection group,and the difference between the two groups was statistically significant(P<0.05).The D-dimer was(2.21±0.85)mg/L in the sepsis group and(1.03±0.66)mg/L in the general infection group,and the difference between the two groups was also statistically significant(P<0.05).The area under the ROC curve for the determination of septic arthritis combined with sepsis by D-dimer was 0.814(95%CI:0.702-0.927),and the optimal threshold was 2.20 mg/mL.The area under the ROC curve for the determination of septic arthritis combined with sepsis by procalcitonin was 0.891(95%CI:0.809-0.973),and the optimal threshold was 3.85 ng/mL.Conclusion D-dimer and procalcitonin can be used as reference indicators to assist in the determination of septic arthritis’ condition.
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