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夏婷婷 曾克非▲.三种促排卵药物对子宫内膜容受性的影响[J].中国现代医生,2021,59(27):54-58
三种促排卵药物对子宫内膜容受性的影响
Effect of three ovulation induction drugs on endometrial receptivity
  
DOI:
中文关键词:  尿促性腺激素  来曲唑  克罗米芬  促排卵治疗  子宫内膜容受性
英文关键词:Human menopausal gonadotrophin  Letrozole  Clomiphene  Ovulation induction therapy  Endometrial receptivity
基金项目:江西省吉安市指导性科技计划项目(吉市科计字〔2020〕20 号第50 号)
作者单位
夏婷婷 曾克非▲ 井冈山大学附属医院生殖医学科江西吉安 343000 
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中文摘要:
      目的 分析尿促性腺激素(HMG)、来曲唑(LE)、克罗米芬(CC)三种促排卵药物对子宫内膜容受性的影响。方法 选取150例排卵功能障碍致不孕症患者作为研究对象,将其分为HMG 组、LE 组、CC 组,每组各50例,三组患者分别单药应用HMG、LE、CC 作为促排卵治疗方案,然后行宫腔内人工授精(IUI)治疗。对三组患者促排卵治疗前、HCG 注射日的子宫内膜容受性指标及血清激素水平进行检测和分析。对三组患者的临床妊娠率进行观察和对比。结果 在促排卵治疗后,LE 组患者治疗后的子宫内膜厚度、子宫内膜容积、VI、FI、VFI水平高于HMG 组或CC 组,子宫动脉PI、RI、S/D水平低于HMG 组或CC 组,HMG 组患者的VI、FI、VFI水平高于CC 组,HMG 组患者治疗后的血清FSH、E2水平高于CC 组或LE 组,血清LH水平低于CC 组或LE 组,LE 组患者的临床妊娠率高于其他两组,差异均有统计学意义(P<0.05)。结论 在针对排卵功能障碍致不孕症患者的单药促排卵治疗中,相对于应用CC 方案或HMG 方案,应用LE 方案可改善患者的子宫内膜容受性指标,血清性激素水平波动较小,临床妊娠率明显提高。
英文摘要:
      Objective To analyze the effects of three ovulation induction drugs,human menopausal gonadotrophin(HMG),letrozole(LE)and clomiphene(CC),on endometrial receptivity.Methods A total of 150 infertility patients caused by ovulatory dysfunction were selected as the research objects and divided into the HMG group,the LE group and the CC group,with 50 patients in each group.Patients in the three groups were treated with HMG,LE and CC as the ovulation induction regimen,and then were treated with intrauterine artificial insemination(IUI).The endometrial receptivity indexes and serum hormone levels of patients in the three groups before ovulation induction treatment and on the day of HCG injection were detected and analyzed.The clinical pregnancy rates of the three groups were observed and compared.Results After ovulation induction treatment,in the LE group,the endometrial thickness,endometrial volume,and the levels of VI,FI and VFI were higher than those in the HMG group or the CC group;the levels of PI,RI and S/D in the uterine artery were lower than those in the HMG group or the CC group.The levels of VI,FI and VFI in the HMG group were higher than those in the CC group.After treatment,in the HMG group,the serum FSH and E2 levels were higher than those in the CC group or the LE group,while the serum LH levels were lower than those in the CC group or the LE group.The clinical pregnancy rate in the LE group was higher than that in the other two groups.The above differences were all statistically significant(P<0.05).Conclusion In the single-drug ovulation induction therapy for infertility patients with ovulatory dysfunction,compared with the application of CC or HMG regimen,the application of LE regimen can improve endometrial receptivity indexes,with less fluctuation of the serum sex hormone level and significant increase in the clinical pregnancy rate.
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