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贾名辉.小剂量肾上腺素在院前急救中用于重症支气管哮喘抢救的临床抢救效果[J].中国现代医生,2021,59(23):79-82
小剂量肾上腺素在院前急救中用于重症支气管哮喘抢救的临床抢救效果
The clinical rescue effect of low-dose epinephrine in the rescue of severe bronchial asthma in pre-hospital emergency
  
DOI:
中文关键词:  重症支气管哮喘  院前急救  小剂量肾上腺素  氨茶碱  甲泼尼龙  抢救效果
英文关键词:Severe bronchial asthma  Pre-hospital emergency  Low-dose epinephrine  Aminophylline  Methylprednisolone  Rescue effect
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作者单位
贾名辉 南京市中医院急诊科江苏南京 210001 
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中文摘要:
      目的 探讨在重症支气管哮喘院前急救过程中应用小剂量肾上腺素的临床抢救效果。方法 选取2019年1月至2020年11月南京市中医院急诊科收治的56例重症支气管哮喘患者作为研究对象,回顾性分析患者的临床资料,根据抢救方案的不同分为对照组与研究组,每组各28例。对照组采用急诊常规抢救方案,研究组在常规抢救方案基础上继续给予小剂量肾上腺素(总剂量不超过1 mg)。比较两组生命体征(呼吸、心率和血氧饱和度)、急救效果和不良反应。结果 两组治疗前的呼吸、心率和血氧饱和度比较,差异无统计学意义(P>0.05);两组患者治疗10 min、20 min 和30 min 后的呼吸和心率水平均低于本组治疗前,血氧饱和度高于本组治疗前,差异有统计学意义(P<0.05);研究组治疗10 min、20 min 和30 min 后呼吸和心率水平低于对照组,血氧饱和度水平高于对照组,差异有统计学意义(P<0.05)。研究组急救总有效率为92.86%,高于对照组的71.43%,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 在重症支气管哮喘患者的院前急救中给予小剂量的肾上腺素治疗可以有效改善患者的生命体征,在提高患者的急救效果的同时,不会增加不良反应的发生,保障患者急救的有效性和安全性,临床应用价值显著。
英文摘要:
      Objective To explore the clinical rescue effect of low-dose epinephrine during pre-hospital emergency treatment of severe bronchial asthma.Methods Fifty-six patients with severe bronchial asthma admitted to the emergency department of Nanjing Hospital of Traditional Chinese Medicine in Jiangsu Province from January 2019 to November 2020 were selected as the research objects.The clinical data of the patients were retrospectively analyzed.According to the different rescue plans,they were divided into the control group and the study group,with 28 cases in each group.The control group was given the emergency routine rescue plan,and the study group was given low doses of epinephrine (total dose not exceeding 1 mg) on the basis of the routine rescue plan.The vital signs (respiration,heart rate,and blood oxygen saturation),first aid effect,and adverse reactions were compared between the two groups.Results There was no statistically significant difference in respiration,heart rate,and blood oxygen saturation between the two groups before treatment (P>0.05).The respiration and heart rate levels of patients of two groups group after treatment for 10,20,and 30 minutes were lower than those of this group before treatment.The blood oxygen saturation after treatment was higher than before treatment in this group.The difference was statistically significant (P<0.05).After 10 min,20 min,and 30 min treatment in the study group,the respiration and heart rate levels were lower than those of the control group,and the blood oxygen saturation level was higher than the control group.The difference was statistically significant(P<0.05).The total effective rate of first aid in the study group (92.86%) was higher than 71.43% in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion In the pre-hospital emergency treatment of patients with severe bronchial asthma,a small dose of epinephrine therapy can effectively improve the patient′s vital signs.While improving the patient′s first aid effect,it will not increase the occurrence of adverse reactions.It ensures the effectiveness and safety of the patient′s first aid and has significant clinical application value.
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