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张淑瑛1 蒋丽娟1▲ 马锦洪1 邵小南2.不同透析方式对CKD 5期患者HGB水平影响的横断面研究[J].中国现代医生,2021,59(21):120-125
不同透析方式对CKD 5期患者HGB水平影响的横断面研究
Cross-sectional study of effect of different dialysis methods on HGB levels in patients with CKD Stage 5
  
DOI:
中文关键词:  慢性肾脏病  血液透析  腹膜透析  血红蛋白
英文关键词:Chronic kidney disease  Hemodialysis (HD)  Peritoneal dialysis (PD)  Hemoglobin (HGB)
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作者单位
张淑瑛1 蒋丽娟1▲ 马锦洪1 邵小南2 1.苏州大学附属第三医院检验科江苏常州 2130032.苏州大学附属第三医院核医学科江苏常州 213003 
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中文摘要:
      目的 探讨不同透析方式对慢性肾脏病(Chronic kidney disease,CKD)5 期患者的血红蛋白(Hemoglobin,HGB)水平的影响。方法 回顾性分析2014 年2 月至2019 年12 月苏州大学附属第三医院肾内科CKD5 期患者835例,按透析方式分为未透析组(n=273),血液透析(Hemodialysis,HD)组(n=384),腹膜透析(Peritoneal dialysis,PD)组(n=178),收集三组患者入院时的一般资料和实验室指标。结果 三组患者HGB 比较,差异有统计学意义(P<0.05),HD组[(95.3± 22.6)g/L]>PD组[(93.7±20.1)g/L]>未透析组[(85.7± 21.4)g/L]。在充分调整混杂因素后,透析方式差别与HGB 的提高有显著关联,回归系数β 为5.328(95%CI:1.487~9.168,P=0.007),尤其在PD组相对于未透析组,回归系数β 为11.293(95%CI:3.469~19.009,P=0.005)。曲线拟合显示,HGB 水平随不同透析方式逐渐升高,分别为未透析组81.9 g/L(95%CI:76.1~87.7),HD组84.7 g/L(95%CI:79.3~90.2),PD组93.2 g/L(95%CI:86.2~100.1),以PD组HGB 水平最高。结论 不同透析方式会影响CKD5 期患者的HGB 水平,且PD 对HGB 的影响最小。
英文摘要:
      Objective To explore the effect of different dialysis methods on hemoglobin (HGB) levels in patients with chronic kidney disease (CKD) stage 5.Methods A total of 835 patients with CKD stage 5 in the Department of Nephrology,the Third Affiliated Hospital of Soochow University from February 2014 to December 2019 were retrospectively analyzed.According to dialysis methods,they were divided into the non-dialysis group (273 patients),the hemodialysis(HD) group (384 patients),and the peritoneal dialysis (PD) group (178 patients).The general data and laboratory indicators on admission of the three groups were collected.Results For HGB,statistically significant differences were observed among the three groups (P<0.05),with the HD group [(95.3±22.6)g/L] >the PD group [(93.7±20.1)g/L] >the nondialysis group [(85.7±21.4)g/L].After adequate adjustment for confounding factors,differences in dialysis methods were significantly associated with the increased HGB,with the regression coefficient β of 5.328 (95%CI:1.487-9.168,P=0.007),especially for that of the PD group relative to the non-dialysis group,with the regression coefficient β of 11.293 (95%CI:3.469-19.009,P=0.005).The curve fitting showed that the level of HGB increased gradually with different dialysis methods,which were 81.9 g/L in the non-dialysis group (95%CI:76.1-87.7),84.7 g/L in the HD group (95%CI:79.3-90.2),and 93.2 g/L in the PD group (95%CI:86.2-100.1),and the HGB level was the highest in PD group.Conclusion Different dialysis methods can affect the level of HGB in CKD stage 5 patients,and PD has the least effect on HGB.
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