| 孙兆娟1 牟晓映2 薛玉玮3▲.幽门螺杆菌特异性IgM和IgG抗体、CA724、CEA联合检测对胃癌早期的临床诊断价值分析[J].中国现代医生,2021,59(21):111-113+119 |
| 幽门螺杆菌特异性IgM和IgG抗体、CA724、CEA联合检测对胃癌早期的临床诊断价值分析 |
| Analysis of clinical value of combined detection of Helicobacter pylori-specific IgM and IgG,CA724 and CEA in diagnosing gastric cancer at early stage |
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| DOI： |
| 中文关键词: 胃癌 幽门螺杆菌 IgM 抗体 IgG 抗体 CA724 CEA |
| 英文关键词:Gastric cancer Helicobacter pylori IgM antibody IgG antibody CA724 CEA |
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| 中文摘要: |
| 目的 探讨幽门螺杆菌（Hp）特异性IgM 抗体、IgG 抗体，以及肿瘤标志物指标糖类抗原724（CA724）、癌胚抗原（CEA）联合检测对胃癌早期临床诊断的价值。方法 收集2018 年2 月至2020 年2 月我院收治的胃癌患者、胃良性病变患者、健康志愿者的血清标本资料各50例，分别进行IgM 抗体、IgG 抗体的检测、肿瘤标志物指标CA724、CEA 的检测。比较各组受检者相关指标阳性率差异及联合检测结果，分析在胃癌诊断中的价值。结果 胃癌组IgM 抗体、IgG 抗体、CA724、CEA 阳性率高于胃良性病变组、健康志愿者组，差异有统计学意义（P＜0.05）；胃良性病变组IgM 抗体阳性率高于健康志愿者组，差异有统计学意义（P＜0.05）；胃良性病变组和健康志愿组在IgG 抗体、CA724、CEA 比较中，差异无统计学意义（P＞0.05）。胃癌组联合检测阳性率高于胃良性病变组、健康志愿者组，差异有统计学意义（P＜0.05）。结论Hp 特异性IgM 抗体、IgG 抗体，CA724、CEA 可用于胃癌的早期诊断，HP 感染与胃癌的发生密切相关，IgM 抗体、IgG 抗体，CA724、CEA 联合检测可显著提升胃癌的检出率，减少漏诊的发生，对及早发现胃癌有重要价值。 |
| 英文摘要: |
| Objective To investigate the value of the combined detection of Helicobacter pylori (Hp)-specific IgM,IgG,and tumor markers such as carbohydrate antigen 724(CA724) and carcinoembryonic antigen(CEA) in the early clinical diagnosis of gastric cancer(GC).Methods Serum samples were collected from 50 patients with GC,50 patients with benign gastric lesions and 50 healthy volunteers who were admitted to our hospital from February 2018 to February 2020.IgM,IgG,tumor marker CA724 and CEA were detected.The differences in the positive rate of related indexes in each group and the results of combined detection were compared,and their values in the diagnosis of GC were analyzed.Results The positive rates of IgM,IgG,CA724 and CEA were higher in GC group than those in the benign gastric lesion group and the healthy volunteers group,with statistically significant differences (P＜0.05).The positive rate of IgM antibody in the benign gastric lesion group was higher than that in the healthy volunteers group,with statistically significant differences (P＜0.05).There were not statistically significant differences in IgG,CA724 and CEA among groups(P＞0.05).The positive rate of the combined detection was higher in GC group than that in the benign gastric lesions group and the healthy volunteers group,with statistically significant differences (P＜0.05).Conclusion Hp-specific IgM,IgG,CA724 and CEA can be used for the early diagnosis of GC.Hp infection is closely related to the occurrence of GC.Combined detection of IgM,IgG,CA724 and CEA can significantly improve the detection rate and sensitivity of GC,reduce the occurrence of missed diagnosis,which shows a significant value for the early detection of GC. |
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