| 麻 爽 朱德淼▲ 陶百慧 高迪迪.化疗诱导闭经对激素受体阳性乳腺癌患者预后的影响[J].中国现代医生,2021,59(21):45-48 |
| 化疗诱导闭经对激素受体阳性乳腺癌患者预后的影响 |
| Effect of chemotherapy-induced amenorrhea on the prognosis of patients with hormone receptor-positive breast cancer |
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| DOI： |
| 中文关键词: 乳腺癌 化疗诱导闭经 预后 激素受体阳性 |
| 英文关键词:Breast cancer Chemotherapy-induced amenorrhea Prognosis Hormone receptor-positive |
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| 中文摘要: |
| 目的 回顾性分析激素受体（Hormone receptor，HR）阳性乳腺癌患者化疗诱导闭经（Chemotherapy-induced amenorrhea，CIA）的发生与患者预后的关系。方法 回顾性分析2014 年1 月至2017 年12 月锦州医科大学附属第一医院收治的194例绝经前乳腺癌患者，入组患者手术治疗后均行规律辅助化疗，且未接受卵巢功能抑制（Ovarian suppression treatment，OST）治疗。随访患者无病生存期（Disease free survival，DFS）并分析CIA 的出现与DFS 之间的关系。依照患者HR 情况将患者分为两组，比较亚组中CIA 发生与DFS 之间的关系。结果 中位随访时间为51 个月，有119例发生CIA，发生率为61.34%（119/194），发生CIA组与未发生CIA组DFS 差异显著，P=0.014，92.43% vs.82.67%。HR（+）亚组146例患者中，发生CIA 的患者DFS 显著高于无CIA 患者（P=0.023，95.65%vs 87.04%）。而在HR（-）亚组48例患者中，两者差异不明显（81.48% vs 71.43%，P=0.488）。结论 化疗诱导闭经的发生对患者预后有积极影响，这种影响在激素受体阳性患者中更为明显。 |
| 英文摘要: |
| Objective To retrospectively analyze the relationship between the occurrence of chemotherapy-induced amenorrhea (CIA) and prognosis in patients with hormone receptor (HR)-positive breast cancer.Methods A total of 194 premenopausal breast cancer patients admitted to the First Affiliated Hospital of Jinzhou Medical University from January 2014 to December 2017 were retrospectively analyzed.All patients enrolled in this study were treated with regular adjuvant chemotherapy after surgery and did not receive ovarian suppression treatment (OST).Patients were followed up for disease free survival (DFS) and the relationship between the occurrence of CIA and DFS was analyzed.These patients were divided into two groups according to their HR status，and the relationship between the occurrence of CIA and DFS was compared in subgroups.Results At a median follow-up of 51 months，119 patients had CIA，with an incidence of 61.34% (119/194).There was significant difference in DFS between the group with and without CIA (P=0.014，92.43%vs.82.67%).In the HR (+) subgroup of 146 patients，the DFS in patients with CIA was significantly higher than those without CIA (P=0.023，95.65% vs.87.04%).However，in the HR (-) subgroup of 48 patients，there was no significant difference in DFS between patients with CIA and those without CIA (81.48% vs.71.43%，P=0.488).Conclusion The occurrence of chemotherapy-induced amenorrhea has a positive effect on the prognosis of patients，which is more significant in hormone receptor-positive patients. |
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