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刘大鹏.ESA联合铁剂治疗肾性贫血的疗效观察及其对促红素、亚铁离子的影响[J].中国现代医生,2021,59(20):40-42
ESA联合铁剂治疗肾性贫血的疗效观察及其对促红素、亚铁离子的影响
Observation on the therapeutic efficacy of ESA combined with ferralium on renal anemia and its impacts on erythropoietin and ferrous ion
  
DOI:
中文关键词:  肾性贫血  ESA  蔗糖铁  静脉滴注  促红素  亚铁离子
英文关键词:Renal anemia  Erythropoiesis-stimulating agents  Iron sucrose  Intravenous drip  Erythropoietin  Ferrous ion
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作者单位
刘大鹏 辽宁省健康产业集团阜新矿总医院全科病房辽宁阜新 123000 
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中文摘要:
      目的 探讨ESA 联合铁剂对肾性贫血的治疗效果及对患者体内促红素、亚铁离子水平产生的影响作用。方法 将我院自2018 年1 月至2020 年1 月间收治的肾性贫血患者86 例作为研究对象,按照随机数字表法分为研究组和对照组,每组各43 例。研究组给予红细胞生成刺激素(ESA)联合蔗糖铁静脉滴注,对照组单纯使用ESA进行治疗,观察两组患者的临床疗效、血细胞比容、血红蛋白、血清铁蛋白水平及不良反应发生情况。结果 研究组患者的临床治疗总有效率为95.35%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗前两组的血细胞比容、血红蛋白、血清铁蛋白水平比较,差异无统计学意义(P>0.05),治疗后两组患者的血细胞比容、血红蛋白、血清铁蛋白水平较治疗前均明显升高,且研究组的血细胞比容、血红蛋白、血清铁蛋白高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者不良反应总发生率为4.65%,低于对照组的20.93%,差异有统计学意义(P<0.05)。结论 肾性贫血采用ESA 联合蔗糖铁制剂治疗可以有效的改善患者临床症状,改善血液环境,对于患者病情的控制具有促进作用。
英文摘要:
      Objective To investigate the therapeutic efficacy of erythropoiesis-stimulating agents (ESA) combined with ferralium on renal anemia and its impacts on erythropoietin and ferrous ion levels in patients.Methods A total of 86 patients with renal anemia admitted to our hospital from January 2018 to January 2020 were selected as the research objects and divided into the study group and the control groupaccording to the random number table method,with 43 cases in each group.The study group was treated with ESA combined with iron sucrose intravenous drip,while the control group was treated with single ESA.The clinical efficacy,the hematocrit,hemoglobin,serum ferritin levels,and the incidence of adverse reactions of patients in the two groups were observed.Results The total effective rate of clinical treatment in the study group was 95.35%,which was higher than that of 76.74% in the control group,with statistically significant difference between the two groups (P<0.05).Before treatment,the hematocrit,there was no statistically significant differences of hemoglobin and serum ferritin between the two groups (P>0.05).After treatment,the hematocrit,hemoglobin,and serum ferritin levels of patients in the two groups were significantly higher than those before the treatment,with statistically significant differences(P<0.05).Meanwhile,the hematocrit,hemoglobin and serum ferritin in the study group were higher than those in the control group,with statistically significant differences between the two groups(P<0.05).After treatment,the total incidence of adverse reactions in the study group was 4.65%,which was lower than that of 20.93% in the control group,with statistically significant difference between the two groups(P<0.05).Conclusion The treatment of renal anemia with ESA combined with iron sucrose preparation can effectively improve the clinical symptoms and blood environment,and promote the control of condition in patients.
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