| 刘同博.阿德福韦酯联合安络化纤丸对乙型肝炎肝硬化的治疗价值[J].中国现代医生,2021,59(19):120-123 |
| 阿德福韦酯联合安络化纤丸对乙型肝炎肝硬化的治疗价值 |
| Therapeutic value of adefovir dipivoxil combined with Anluo Huaxian Pills on hepatitis B cirrhosis |
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| DOI： |
| 中文关键词: 乙型肝炎肝硬化 阿德福韦酯 安络化纤丸 肝纤维化 肝功能 HBV-DNA |
| 英文关键词:Hepatitis B cirrhosis Adefovir dipivoxil Anluo Huaxian Pills Liver fibrosis Hepatic function HBV-DNA |
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| 中文摘要: |
| 目的 分析阿德福韦酯+安络化纤丸在乙型肝炎肝硬化患者中的治疗效果。方法 选取2019 年2 月至2020 年3 月我院收治的68 例乙型肝炎肝硬化患者，随机分为两组，观察组（n=34）采用阿德福韦酯+安络化纤丸，对照组（n=34）单纯采用阿德福韦酯治疗，比较两组患者临床疗效、治疗前后层黏连蛋白（LN）、透明质酸（HA）、Ⅳ型胶原（Ⅳ-C）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBIL）水平，同时比较HBVDNA 转阴率、HBeAg 转阴率和不良反应总发生率。结果 观察组总有效率为97.06%，明显高于对照组的79.41%，差异有统计学意义（P<0.05）；治疗后观察组层黏连蛋白（LN）、透明质酸（HA）、Ⅳ型胶原（Ⅳ-C）水平低于对照组，差异有统计学意义（P<0.05）；治疗后观察组丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBIL）水平低于对照组，差异有统计学意义（P<0.05）；治疗后观察组HBV-DNA 转阴率、HBeAg 转阴率（97.06%、64.71%）均高于对照组（73.53%、35.29%），差异有统计学意义（P<0.05）；观察组不良反应总发生率为5.88%，低于对照组的26.47%，差异有统计学意义（P<0.05）。结论 阿德福韦酯+安络化纤丸治疗乙型肝炎肝硬化，可提高临床疗效，改善肝功能及肝纤维化指标，并在此基础上最大提高HBV-DNA 转阴率，用药安全方便，是较好的联合用药方案。 |
| 英文摘要: |
| Objective?To analyze the therapeutic efficacy of adefovir dipivoxil combined with Anluo Huaxian Pills in patients with hepatitis B cirrhosis.Methods?A total of 68 patients with hepatitis B cirrhosis admitted from February 2019 to March 2020 in our hospital were collected and randomly divided into the observation group(n=34) and the control group (n=34).The observation group was treated with adefovir dipivoxil combined with Anluo Huaxian Pills,while the control group was treated with single adefovir dipivoxil.The clinical efficacy and levels of laminin (LN),hyaluronic acid(HA),type Ⅳprecollagen(Ⅳ-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)before and after treatment,as well as the negative conversion rates of HBV-DNA and HBeAg and the total incidence of adverse reactions (ADRs)were compared between the two groups.Results?The overall response rates in the observation group was 97.06%,which was higher than that of 79.41% in the control group,with statistically significant difference (P<0.05).After treatment,the levels of LN,HA and Ⅳ-C in the observation group were lower than those in the control group (P<0.05).After treatment,the levels of ALT,AST and TBIL in the observation group were lower than those in the control group (P<0.05).After treatment,the negative conversion rates of HBV-DNA and HBeAg in the observation group were 97.06% and 64.71%,which were both higher than those of 73.53% and 35.29% in the control group respectively,with statistically significant differences(P<0.05).The total incidence of ADRs in the observation group was 5.88%,which was lower than that of 26.47%in the control group,with statistically significant difference(P<0.05).Conclusion?Adefovir dipivoxil combined with Anluo Huaxian Pills in the treatment of hepatitis B cirrhosis can improve the clinical efficacy,hepatic function and liver fibrosis index,and on this basis,maximize the negative conversion rate of HBV-DNA.It is safe and convenient to use,which is a better combination medication scheme. |
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