| 徐 莎.乙酰半胱氨酸雾化治疗儿童肺炎的效果及安全性分析[J].中国现代医生,2021,59(19):71-74 |
| 乙酰半胱氨酸雾化治疗儿童肺炎的效果及安全性分析 |
| Efficacy and safety analysis of acetylcysteine atomization in treating pneumonia in children |
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| 中文关键词: 乙酰半胱氨酸 雾化吸入 儿童肺炎 临床症状 炎症因子 不良反应 |
| 英文关键词:Acetylcysteine Atomization inhalation Pneumonia in children Clinical symptoms Inflammatory factors Adverse reaction |
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| 中文摘要: |
| 目的 研究乙酰半胱氨酸雾化吸入治疗儿童肺炎的效果及安全性。方法 选择我院2019 年10 月至2020年7 月诊治的儿童肺炎中选出152 例为对象，以随机数字表法分成对照组（常规综合治疗）和试验组（常规综合治疗+乙酰半胱氨酸雾化吸入），对比两组的总有效率、临床症状缓解时间、住院时间、炎症因子（CRP、PCT 和WBC计数）水平、不良反应发生率。结果 试验组的总有效率（97.37%）高于对照组（88.16%）（P＜0.05）；试验组的临床症状（咳嗽、发热、气促、肺部啰音）缓解时间、住院时间为（4.37±0.65）d、（2.01±0.34）d、（2.95±0.43）d、（5.11±0.87）d、（5.49±1.18）d；对照组为（6.02±0.87）d、（2.69±0.51）d、（3.54±0.56）d、（6.84±1.03）d、（6.67±1.32）d；试验组均短于对照组（P＜0.05）；试验组治疗3 d 后的炎症因子（CRP、PCT 和WBC 计数）分别为（4.3±0.8）mg/L、（0.032±0.005）μg/L、（7.48±0.77）×109 个/L，对照组分别为（6.0±1.1）mg/L、（0.085±0.009）μg/L、（8.63±1.05）×109 个/L，试验组均低于对照组（P＜0.05）；试验组的不良反应发生率（3.96%）略低于对照组（6.58%），但组间差异无统计学意义（P＞0.05）。结论 乙酰半胱氨酸雾化吸入治疗在儿童肺炎治疗中应用有助于患儿临床症状缓解，减轻炎症反应，安全性较高。 |
| 英文摘要: |
| Objective To study the efficacy and safety of acetylcysteine atomization inhalation in the treatment of pneumonia in children.Methods A total of 152 children with pneumonia diagnosed and treated in our hospital from October 2019 to July 2020 were selected as subjects.They were randomly divided into the control group (conventional comprehensive treatment) and the experimental group (conventional comprehensive treatment+acetylcysteine atomization inhalation).The total effective rate,relief time of clinical symptom,hospitalization time,inflammatory factor (CRP,PCT and WBC count) level and adverse reaction incidence rate of the two groups were compared.Results The total effective rate was higher in the experimental group (97.37%) than that in the control group (88.16%) (P<0.05).The relief time of clinical symptoms [cough:(4.37±0.65) d,fever:(2.01±0.34) d,shortness of breath:(2.95±0.43) d,and pulmonary rales:(5.11±0.87) d] and hospitalization time [(5.49±1.18) d] were both shorter in the experimental group than those in the control group [(6.02±0.87) d,(2.69±0.51) d,(3.54±0.56) d,(6.84±1.03) d,(6.67±1.32) d] (P<0.05).The number of inflammatory factors (CRP,PCT and WBC) in the experimental group were (4.3±0.8) mg/L,(0.032±0.005) g/L,(7.48±0.77) ×109/L,respectively,which were lower than those in the control group [(6.0±1.1) mg/L,(0.085±0.009) g/L,(8.63±1.05) ×109/L,respectively] (P<0.05).The incidence of adverse reactions was 3.96% in the experimental group,slightly lower than that in the control group (6.58%),with no significant difference between the groups (P>0.05).Conclusion The application of acetylcysteine atomization inhalation therapy is helpful to relieve clinical symptoms,reduce inflammatory reaction of children′s pneumonia,with higher safety. |
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