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蒋晓春 黄婉立▲ 陈燕娣 翁秋琴.重复经颅磁刺激对精神分裂症患者认知功能的影响[J].中国现代医生,2021,59(19):22-25
重复经颅磁刺激对精神分裂症患者认知功能的影响
Effect of repeated transcranial magnetic stimulation on the cognitive function of patients with schizophrenia
  
DOI:
中文关键词:  重复经颅磁刺激  精神分裂症  认知功能  氯氮平
英文关键词:Repeated transcranial magnetic stimulation  Schizophrenia  Cognitive function  Clozapine
基金项目:浙江省医药卫生科技计划项目(2017KY268)
作者单位
蒋晓春 黄婉立▲ 陈燕娣 翁秋琴 浙江省立同德医院精神科浙江杭州 311122 
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中文摘要:
      目的 探讨重复经颅磁刺激对精神分裂症患者认知功能的影响。方法 选择2019 年7 月至2020 年5 月在本院治疗的60 例精神分裂症患者进行研究。所有患者随机分组,观察组30 例,对照组30 例。对照组给予氯氮平治疗,观察组给予氯氮平与rTMS 治疗。比较两组治疗前后PANSS 评分,智力状况(MMSE)以及认知功能水平(MMSE,BACS SC,HVLT-R,BVMT-R,WMS-ⅢSST,Stroop 色-词测验,WCST)。结果 (1)治疗后,两组PANSS评分较治疗前显著下降,MMSE 评分较治疗前高,差异有统计学意义(P<0.05);观察组治疗后PANSS 评分显著低于对照组,MMSE 评分显著较对照组高,差异有统计学意义(P<0.05)。(2)两组治疗后BACS SC、HVLT-R、BVET-R、WMS-ⅢSST、Stroop-词、Stroop-色、Stroop-色词、WCST 总正确数、完成分类数较治疗前均较治疗前显著提高,差异有统计学意义(P<0.05);两组WCST 总错误数、持续错误数、持续应答数治疗后低于治疗前,差异有统计学意义(P<0.05)。治疗后观察组BACS SC、HVLT-R、BVET-R、WMS-ⅢSST、Stroop-词、Stroop-色、Stroop-色词、WCST 总正确数、完成分类数显著高于对照组,WCST 总错误数、持续错误数、持续应答数较对照组低,差异有统计学意义(P<0.05)。结论 在药物治疗基础上给予重复经颅磁刺激治疗,可显著改善患者精神分裂症评分以及认知功能。
英文摘要:
      Objective To investigate the effect of repeated transcranial magnetic stimulation on the cognitive function of patients with schizophrenia.Methods A total of 60 patients with schizophrenia who were treated in our hospital from July 2019 to May 2020 were selected for research.All patients were randomly divided into 30 cases in the observation group and 30 cases in the control group.The control group was given clozapine,and the observation group was given clozapine and rTMS for treatment.The PANSS score,mental status (MMSE) and cognitive function level (MMSE,BACS SC,HVLT-R,BVMT-R,WMS-ⅢSST,Stroop color-word test,WCST) were compared before and after treatment between the two groups.Results (1)After treatment,the PANSS score in both groups was significantly lower than that before treatment,and the MMSE score was higher than that before treatment,with significant difference(P<0.05);after treatment,the PANSS score in the observation group was significantly lower than that in the control group,and the MMSE score was significantly higher than that in the control group,with significant difference(P<0.05).(2)After treatment,BACS SC,HVLT-R,BVET-R,WMS-ⅢSST,Stroop-word,Stroop-color,Stroop-color word,WCST total correct number,and the number of completed classifications were higher than those before treatment in both groups,and the differences were statistically significant (P<0.05);the total number of WCST errors,the number of repeated errors,and the number of repeated responses after treatment were lower than those before treatment,and the differences were significant (P<0.05).After treatment,BACS SC,HVLT-R,BVET-R,WMS-ⅢSST,Stroop-word,Stroop-color,Stroop-color word,WCST total correct number and the number of completed classifications were significantly higher than those in the control group.The total number of WCST errors,the number of repeated errors,and the number of repeated responses were lower than those in the control group,with significant differences(P<0.05).Conclusion Repetitive transcranial magnetic stimulation therapy based on drug therapy can significantly improve the schizophrenia score and cognitive function of patients.
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