| 胡一川.羟苯磺酸钙治疗非增生性糖尿病视网膜病变[J].中国现代医生,2021,59(19):18-21 |
| 羟苯磺酸钙治疗非增生性糖尿病视网膜病变 |
| Efficacy of calcium dobesilate in the treatment of non-proliferative diabetic retinopathy |
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| 中文关键词: 非增生性 糖尿病视网膜病变 羟苯磺酸钙 阿卡波糖 二甲双胍 |
| 英文关键词:Non-proliferative Diabetic retinopathy Calcium dobesilate Acarbose Metformin |
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| 中文摘要: |
| 目的 观察羟苯磺酸钙治疗非增生性糖尿病视网膜病变的临床疗效。方法 选择我院2018 年1 月至2020年4 月收治的非增生性糖尿病视网膜病变（NPDR）患者64 例，按照随机数字表法分为观察组和对照组，每组各32 例，对照组患者给予基础治疗，观察组在基础治疗的同时给予羟苯磺酸钙治疗。评价两组患者在治疗后的临床疗效；检测两组患者在治疗前后血糖控制情况；检测两组患者治疗前后视力水平、微血管瘤数量、出血斑面积、黄斑厚度；观察两组患者不良反应发生情况。结果 ①观察组总有效率为93.75%（30/32），明显高于对照组的71.88%（23/32）（P<0.05）；②治疗前后，两组患者空腹血糖、餐后2 h 血糖及糖化血红蛋白水平比较，差异无统计学意义（P>0.05）；③治疗前，两组患者视力水平、微血管瘤数量、出血斑面积及黄斑厚度比较，差异无统计学意义（P>0.05）。治疗后，两组患者视力水平、微血管瘤数量、出血斑面积及黄斑厚度较治疗前明显改善，且观察组视力水平高于对照组，微血管瘤数量、出血斑点面积、黄斑厚度少于对照组（P<0.05）；④两组患者不良反应发生率[15.62%（5/32）vs.12.50%（4/32）]比较，差异无统计学意义（P>0.05）。结论 羟苯磺酸钙能够改善非增生性糖尿病视网膜病变，提高临床疗效，值得推广应用。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of calcium dobesilate in the treatment of non-proliferative diabetic retinopathy (NPDR).Methods Sixty-four NPDR patients admitted to our hospital from January 2018 to April 2020 were selected.They were randomly divided into the observation group and the control group,with 32 cases in each group.Patients in the control group were given basic treatment,while patients in the observation group were given calcium dobesilate and basic treatment.The clinical efficacy of the two groups after treatment was evaluated.The blood glucose of the two groups before and after treatment was detected.The visual acuity,the number of microhemangioma,the area of bleeding spots and the thickness of macula were detected before and after treatment.The adverse reactions(ADRs) of the two groups were observed.Results ①The total effective rate of the observation group was 93.75%(30/32),which was significantly higher than that of the control group (71.88%,23/32)(P<0.05).②There were no statistically significant differences in the levels of fasting blood glucose,2 hour postprandial blood glucose and glycosylated hemoglobin between the two groups before and after treatment (P>0.05).③Before treatment,there were no statistically significant differences in the visual acuity,the number of microhemangioma,the area of bleeding spots and the thickness of macula between the two groups (P>0.05).After treatment,the visual acuity,the number of microhemangioma,the area of bleeding spots and the thickness of macula in the two groups were significantly improved compared with those before treatment,the visual acuity in the observation group was higher than that in the control group,the number of microvessels，the area of bleeding spots and the thickness of macula in the observation group was less than that in the control group(P<0.05).④There was no significant difference in the incidence of ADRs between the two groups [15.62% (5/32)vs.12.50% (4/32)](P>0.05).Conclusion Calcium dobesilate can improve NPDR and improve clinical efficacy,which is worthy of popularization and application. |
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