| 胡俊华1 胡艳秋2▲ 许红霞1 周 迪1.佳木斯市艾滋病抗病毒治疗患者生存率及影响因素分析[J].中国现代医生,2021,59(19):10-13 |
| 佳木斯市艾滋病抗病毒治疗患者生存率及影响因素分析 |
| Analysis of survival rate and influencing factors of AIDS patients treated with antiviral therapy in Jiamusi City |
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| 中文关键词: 艾滋病 抗病毒治疗 生存率 影响因素 |
| 英文关键词:AIDS Antiviral therapy Survival rate Influencing factors |
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| 中文摘要: |
| 目的 了解佳木斯市艾滋病病毒感染和艾滋病患者（HIV/AIDS）抗病毒治疗（HAART）生存率，并分析影响因素。方法 采用回顾性队列研究，通过《中国疾病预防控制信息系统》采集佳木斯市疾病预防控制中心2009 年6 月至2019 年7 月收治的HIV/AIDS HAART 患者的一般资料，采用寿命表法计算生存率，采用多因素Cox 比例风险模型分析生存时间的影响因素。结果 共纳入1986 例HIV/AIDS HAART 患者，其中死于HIV/AIDS 相关疾病48 例（占2.42%），HIV/AIDS HAART 的1、3、5、10 年累积生存率分别为98.44%、97.84%、97.47%、96.29%；多因素Cox 比例风险模型分析结果显示，经血感染HIV（HR=3.125）、开始治疗时年龄30～（HR=4.518）、开始治疗时年龄50～（HR=15.897）、有漏服药（HR=5.647）的HIV/AIDS HAART 患者死亡的危险较大，高中及以上文化程度（HR=0.264）、基线CD4+T 淋巴细胞计数＞350 个/μL（HR=0.183）的HIV/AIDS HAART 患者死亡的危险较小。结论 2009 年6 月至2019 年7 月佳木斯市HIV/AIDS HAART 患者生存率较高，经血感染、HAART 时年龄较大、有漏服药是HIV/AIDS HAART 患者生存的危险因素，高中及以上文化程度、基线CD4+T 淋巴细胞计数＞350 个/μL是HIV/AIDS HAART 患者生存的保护因素。 |
| 英文摘要: |
| Objective To understand the survival rate of HIV/AIDS patients (HIV/AIDS) treated with antiretroviral therapy(HAART) in Jiamusi City and analyze the influencing factors.Methods A retrospective cohort study was used to collect general data of HIV/AIDS HAART patients admitted to Jiamusi Center for Disease Control and Prevention from June 2009 to July 2019 through the "China Disease Prevention and Control Information System".The survival rate was calculated using the life table method.The multivariate Cox proportional hazard model was used to analyze the factors affecting survival time.Results A total of 1986 HIV/AIDS HAART patients were enrolled,of which 48 died of HIV/AIDS-related diseases (2.42%).The 1,3,5,and 10-year cumulative survival rates of HIV/AIDS HAART were 98.44%,97.84%,97.47%,96.29%,respectively.Multivariate Cox proportional hazard model analysis results showed that bloodinfected HIV(HR=3.125),age 30～(HR=4.518)at the start of treatment,age 50～(HR=15.897)at the beginning of treatment,HIV/AIDS HAART patients with missed medication (HR=5.647) were at greater risk of death.The HIV/AIDS HAART patients with high school education and above(HR=0.264),baseline CD4+T lymphocyte count＞350/μL (HR=0.183) had a lower risk of death.Conclusion From June 2009 to July 2019,the survival rate of HIV/AIDS HAART patients in Jiamusi City is relatively high.Blood infection,older age at HAART,and missed medication are risk factors for the survival of HIV/AIDS HAART patients.High school education and above,baseline CD4+ T lymphocyte count＞350/μL are protective factors for the survival of HIV/AIDS HAART patients. |
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