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林 霞.免疫球蛋白联合地塞米松治疗急性吉兰-巴雷综合征的效果[J].中国现代医生,2021,59(15):101-103+108
免疫球蛋白联合地塞米松治疗急性吉兰-巴雷综合征的效果
The efficacy of immunoglobulin combined with dexamethasone in the treatment of acute Guillain-Barre syndrome
  
DOI:
中文关键词:  吉兰-巴雷综合征  免疫球蛋白  地塞米松  效果
英文关键词:Guillain-Barre syndrome  Immunoglobulin  Dexamethasone  Efficacy
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作者单位
林 霞 甘肃省天水市第一人民医院神经内一科甘肃天水 741000 
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中文摘要:
      目的 探讨免疫球蛋白联合地塞米松治疗急性吉兰-巴雷综合征的效果。方法 回顾性分析2016 年1 月至2020 年10 月我院收住的急性吉兰-巴雷综合征患者45 例,免疫球蛋白联合地塞米松治疗组23 例,单纯免疫球蛋白治疗组22 例,分别对比两组患者的治疗效果、临床转归。结果 免疫球蛋白联合地塞米松治疗组总有效率显著高于单纯免疫球蛋白治疗组,而无效率则明显低于单纯免疫球蛋白治疗组,差异有统计学意义(P<0.05)。免疫球蛋白联合地塞米松治疗组住院时间为(15.0±5.5)d,明显短于单纯免疫球蛋白治疗组的(26.0±8.8)d,差异有统计学意义(P<0.05)。结论 免疫球蛋白联合地塞米松治疗急性吉兰-巴雷综合征疗效显著,在基层具有广泛的应用前景。
英文摘要:
      Objective To investigate the efficacy of immunoglobulin combined with dexamethasone in the treatment of acute Guillain-Barre syndrome.Methods A total of 45 patients with acute Guillain-Barre syndrome admitted to our hospital from January 2016 to October 2020 were analyzed retrospectively,and they were divided into the immunoglobulin combined with dexamethasone group(n=23) and the single immunoglobulin group (n=22),respectively.The therapeutic efficacy and clinical outcome of patients in the two groups were compared,respectively.Results The overall response rate in the immunoglobulin combined with dexamethasone group was significantly higher than that in the single immunoglobulin group,while the ineffective rate was significantly lower than that in the immunoglobulin treatment group,with statistically significant differences(P<0.05).The length of stay in the immunoglobulin combined with dexamethasone group was (15.0±5.5)d,which was significantly shorter than that of (26.0±8.8)d in the single immunoglobulin group,with statistically significant differences (P<0.05).Conclusion Immunoglobulin combined with dexamethasone is effective in the treatment of acute Guillain-Barre syndrome,and has broad application prospects at the grass-roots level.
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