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陈 寻1 李海同1 骆云珍1 李 群2 陈晓红1▲.TNFRSF4基因在头颈鳞癌中的表达及预后价值研究[J].中国现代医生,2021,59(15):1-4+封三
TNFRSF4基因在头颈鳞癌中的表达及预后价值研究
The expression and prognostic value of TNFRSF4 gene in head and neck squamous cell carcinoma
  
DOI:
中文关键词:  头颈鳞癌  TNFRSF4  分子标志物  诊断  预后
英文关键词:Head and neck squamous cell carcinoma  TNFRSF4  Molecular markers  Diagnosis  Prognosis
基金项目:浙江省基础公益研究计划项目(GF18H130007);浙江省自然科学基金项目(LGF18H130001)
作者单位
陈 寻1 李海同1 骆云珍1 李 群2 陈晓红1▲ 1.浙江省嘉兴市第二医院耳鼻咽喉头颈外科浙江嘉兴 3140002.宁波市医疗中心李惠利医院耳鼻咽喉头颈外科浙江宁波 315000 
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中文摘要:
      目的 研究TNF 受体超家族成员4(TNF receptor super-family member 4,TNFRSF4,又名OX40 基因)与头颈鳞癌患者的临床特征相关性及其预后价值。方法 利用公共数据库The Cancer Genome Atlas(TCGA,https://portal.gdc.cancer.gov/)获取502 例头颈鳞癌患者的TNFRSF4 表达水平,并且分析其表达水平的预后价值。结果 本项研究证实头颈鳞癌组织中TNFRSF4 表达水平显著高于癌旁组织,并且TNFRSF4 的表达与头颈鳞癌患者的淋巴结转移及T 分期密切相关,提示TNFRSF4 参与头颈鳞癌的进展。通过Cox 回归模型分析证实TNFRSF4 表达能够成为头颈鳞癌预后评估的独立临床指标。ROC 曲线表明TNFRSF4 诊断头颈鳞癌的曲线下面积(Area under curve,AUC)为0.897,敏感度和特异度分别是84.1%和85.0%。而TNFRSF4 启动子区域甲基化水平是影响其表达水平的重要因素。结论 TNFRSF4 基因在头颈鳞癌发生发展过程中发挥重要作用,TNFRSF4 基因检测可能作为潜在的头颈鳞癌诊断标志物,是判断头颈鳞癌预后的临床指标。
英文摘要:
      Objective To study the correlation between TNF receptor super-family member 4 (TNFRSF4,also known as OX40 gene) and the clinical characteristics of patients with head and neck squamous cell carcinoma and its prognostic value.Methods The public database The Cancer Genome Atlas (TCGA,https://portal.gdc.cancer.gov/) was used to obtain the expression level of TNFRSF4 in 502 patients with head and neck squamous cell carcinoma,and the prognostic value of the expression level was analyzed.Results This study confirmed that the expression level of TNFRSF4 in head and neck squamous cell carcinoma tissues was significantly higher than that in adjacent tissues,and that the expression of TNFRSF4 was closely related to the lymph node metastasis and T stage of patients with head and neck squamous cell carcinoma,suggesting that TNFRSF4 was involved in the progression of head and neck squamous cell carcinoma.Cox regression model analysis confirmed that the expression of TNFRSF4 could be an independent clinical indicator for prognostic evaluation of head and neck squamous cell carcinoma.The ROC curve showed that the area under the curve(AUC) of TNFRSF4 in the diagnosis of head and neck squamous cell carcinoma was 0.897,and the sensitivity and specificity were 84.1% and 85.0%,respectively.The methylation level of TNFRSF4 promoter region was an important factor affecting its expression level.Conclusion TNFRSF4 gene plays an important role in the occurrence and development of head and neck squamous cell carcinoma.Detection of TNFRSF4 gene may be used as a potential diagnostic marker for head and neck squamous cell carcinoma and is a clinical indicator for judging the good prognosis of head and neck squamous cell carcinoma.
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