| 湛婉华1 范新钊2 曹 瑛2.2型糖尿病患者下肢血管病变患病率及纤维蛋白原预测其下肢血管病变切点值的研究[J].中国现代医生,2021,59(14):49-51+55+封三 |
| 2型糖尿病患者下肢血管病变患病率及纤维蛋白原预测其下肢血管病变切点值的研究 |
| Study on the prevalence of lower extremity vascular disease and fibrinogen predicting its cut-off value in patients with type 2 diabetes mellitus |
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| DOI： |
| 中文关键词: 2 型糖尿病 下肢血管病变 纤维蛋白原 踝臂指数 |
| 英文关键词:Type 2 diabetes mellitus Lower extremity vascular disease Fibrinogen Ankle-brachial index |
| 基金项目:广东省医学科学技术研究基金项目（A2020271） |
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| 中文摘要: |
| 目的 统计2 型糖尿病住院患者下肢血管病变患病率，分析血浆纤维蛋白原（FIB）与2 型糖尿病下肢血管病变（PAD）的相关性，确定是否可作为预测2 型糖尿病下肢血管病变的临床指标。方法 随机选择2015 年5 月至2018 年3 月在南方医院内分泌代谢科568 例2 型糖尿病住院患者进行血浆纤维蛋白原及踝臂指数（Ankle brachial index，ABI）检查。根据ABI 检测结果分为PAD 组（ABI≤0.9）和非PAD 组（ABI>0.9），每组各56 例，分析两组血浆纤维蛋白原特点。结果 568 例糖尿病患者中下肢病变患病率为9.9%，性别、年龄与纤维蛋白原无明显相关性，ABI 与纤维蛋白原明显相关（P=0.00），应用受试者工作曲线得到敏感度71.4%，特异度80.4%，最佳切点2.69 g/L。结论 血浆纤维蛋白原对糖尿病患者下肢血管病变有较好的敏感性和特异性，当血浆纤维蛋白原＞2.69 g/L 时，提示下肢血管病变风险明显升高。 |
| 英文摘要: |
| Objective The prevalence of lower extremity vascular disease(LEDV) in inpatients with type 2 diabetes mellitus (T2DM) was analyzed,and the correlation between plasma fibrinogen (FIB) and peripheral artery diseases (PAD) in T2DM patients was analyzed to determine whether it can be used as a clinical index to predict LEDV in T2DM patients.Methods A total of 568 inpatients with T2MD were randomly selected from 2015 to 2018 in the Department of Endocrinology and Metabolism of Nanfang Hospital for plasma fibrinogen and ankle-brachial index (ABI).According to ABI results,they were divided into the PAD group (ABI≤0.9) and the non-PAD group (ABI>0.9),each with 56 cases.The plasma fibrinogen characteristics of the two groups were analyzed.Results The prevalence of LEVD in 568 diabetic patients was 9.9%,and there was no correlation with gender,age and fibrinogen.ABI was significantly correlated with fibrinogen(P=0.00).According to the receiver operating curve (ROC),the sensitivity,the specificity,and the optimal cutoff value were 71.4%,80.4% and 2.69 g/L,respectively.Conclusion Plasma fibrinogen has good sensitivity and specificity for LEVD in diabetic patients.When plasma fibrinogen is more than 2.69 g/L,it indicates that the risk of LEVD is significantly increased. |
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