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黄 华.类风湿性关节炎患者25(OH)D3水平变化及其与CRP、RF、RDW的关系[J].中国现代医生,2021,59(11):119-121
类风湿性关节炎患者25(OH)D3水平变化及其与CRP、RF、RDW的关系
Changes of 25 (OH)D3level in patients with rheumatoid arthritis and its correlation with CRP,RF and RDW
  
DOI:
中文关键词:  25-羟基维生素D3  类风湿因子  红细胞分布宽度  C 反应蛋白  类风湿性关节炎
英文关键词:25-hydroxyvitamin D3  Rheumatoid factor  Red blood cell distribution width  C reactive protein  Rheumatoid arthritis
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作者单位
黄 华 广西医科大学第七附属医院 梧州市工人医院检验科广西梧州 543001 
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中文摘要:
      目的 探讨类风湿性关节炎(RA)患者血清25-羟基维生素D3[25(OH)D3]水平的变化,并分析其与CRP、RF、RDW 的关系。方法 选取2018 年1 月至2019 年7 月100 例于我院就诊并诊断为类风湿性关节炎的患者(RA 组)及100 例健康体检人群(对照组)进行研究;根据疾病活动指数将RA 组分为低活动组(n=57)和高活动组(n=43),比较各组25(OH)D3、CRP、RF、RDW 水平,同时对25(OH)D3与CRP、RF、RDW 的相关性进行Pearson相关分析。结果 与正常对照组比较,RA 组25(OH)D3水平明显降低(P<0.05);CRP、RF、RDW 水平明显升高(P<0.05)。高活动组25(OH)D3水平明显低于低活动组(P<0.05),而CRP、RF、RDW 明显高于低活动组(P<0.05)。Pearson 相关分析显示,25(OH)D3与CRP、RF、RDW 呈负相关(r 值分别为-0.380、-0.433、-0.220,P<0.05)。结论 25(OH)D3水平可能与RA 的发生发展及严重程度有一定关系,RA 患者25(OH)D3水平的检测与对病情及治疗效果的判断具有重要价值。
英文摘要:
      Objective To explore the changes of serum 25-hydroxyvitamin D3[25(OH)D3]in patients with rheumatoid arthritis (RA),and to analyze its correlation with CRP,RF and RDW.Methods A total of 100 patients admitted to our hospital and diagnosed as RA (the RA group,n=100) and 100 examined healthy people (the control group,n=100) from January 2018 to July 2019 were researched.According to disease activity index,the RA group was divided into the low activity group(n=57) and the high activity group(n=43).The levels of 25(OH)D3,CRP,RF and RDW in each group were compared,and Pearson correlation analysis was made on the correlation between 25(OH)D3and CRP,RF and RDW at the same time.Results Compared with the normal control group,the level of 25(OH)D3in the RA group decreased significantly(P<0.05).The levels of CRP,RF and RDW increased significantly(P<0.05).The level of 25(OH)D3in the high activity group was significantly lower than that in the low activity group(P<0.05),while CRP,RF and RDW were significantly higher than those in the low activity group(P<0.05).Pearson correlation analysis showed that 25(OH)D3was negatively correlated with CRP,RF and RDW(r=-0.380,-0.433,-0.220 respectively(P<0.05).Conclusion The level of 25(OH)D3can be related to the occurrence,development and severity of RA,and the detection of 25(OH)D3level in patients with RA is of great value in judging the condition and therapeutic efficacy.
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