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张 雪.左氧氟沙星和卷曲霉素联合治疗对肺结核患者痰结核菌素转阴比率的影响[J].中国现代医生,2021,59(11):108-111
左氧氟沙星和卷曲霉素联合治疗对肺结核患者痰结核菌素转阴比率的影响
Effect of levofloxacin combined with capreomycin on negative conversion ratio of sputum tuberculin in patients with pulmonary tuberculosis
  
DOI:
中文关键词:  左氧氟沙星  卷曲霉素  肺结核  痰结核菌素
英文关键词:Levofloxacin  Capreomycin  Tuberculosis  Sputum tuberculin
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作者单位
张 雪 沈阳市第十人民医院结核三病房辽宁沈阳 110000 
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中文摘要:
      目的 探讨左氧氟沙星和卷曲霉素联合治疗对肺结核患者痰结核菌素转阴比率的影响。方法 选取2018 年9 月至2019 年9 月我院收治的肺结核患者110 例作为研究对象,随机分成观察组和对照组,每组各55 例。对照组采用常规疗法,观察组采用左氧氟沙星和卷曲霉素联合治疗。治疗结束后,比较两组患者治疗后的痰菌转阴率、空洞闭合率以及病灶吸收率变化,比较两组患者治疗前后的免疫指标变化及临床常见不良反应发生率。结果 治疗后,观察组患者的痰菌转阴率、空洞闭合率以及病灶吸收率均高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者CD4+、CD8+、CD3+以及CD4+/CD8+T 比较,差异无统计学意义(P>0.05),治疗后,观察组CD4+及CD3+高于对照组,CD8+低于对照组,差异有统计学意义(P<0.05),治疗后两组CD4+/CD8+比较,差异无统计学意义(P>0.05);治疗后,观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论 左氧氟沙星与卷曲霉素联合治疗时,能够增强患者的痰菌转阴效率,提高空洞的闭合效果以及增大对病灶的吸收程度,值得临床应用。
英文摘要:
      Objective To investigate the effect of levofloxacin combined with capreomycin on the negative conversion ratio of sputum tuberculin of tuberculosis patients.Methods A total of 110 patients with pulmonary tuberculosis admitted to our hospital from September 2018 to September 2019 were selected and they were randomly divided into the observation group and the control group,with 55 cases in each group.The control group was treated with conventional therapy,while the observation group was treated with levofloxacin and capreomycin.After treatment,the negative conversion ratio of sputum tuberculin,the cavity closure rate and the lesion absorption rate of the two groups were compared.Results After treatment,the negative conversion ratio of sputum tuberculin,the cavity closure rate and the lesion absorption rate in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05).Before treatment,there was no significant difference in CD4+,CD8+,CD3+ and CD4+/CD8+ T between the two groups (P>0.05).After treatment,CD4+ and CD3+ in the observation group were higher than those in the control group(P<0.05),and CD8+ was lower than that in the control group(P<0.05).There was no significant difference in CD4+/CD8+ after treatment between the two groups(P>0.05).After treatment,the total incidence of adverse reactions in the observation group was lower than that in the control group,with significant difference(P<0.05).Conclusion Levofloxacin combined with capreomycin can enhance the efficiency of the negative conversion ratio of sputum tuberculin,improve the cavity closure rate and increase the absorption degree of lesions,which is worthy of clinical application.
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