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徐学文 吴向平 马 宏 翁金丽 胡长舟.3种抗精神病药物对精神分裂症患者血糖指标、血脂指标的影响[J].中国现代医生,2021,59(11):104-107
3种抗精神病药物对精神分裂症患者血糖指标、血脂指标的影响
Analysis on the impacts of three antipsychotics on the indexes of blood glucose and blood lipid in schizophrenic patients
  
DOI:
中文关键词:  精神分裂症  抗精神病药物  血糖  血脂
英文关键词:Schizophrenia  Antipsychotic drugs  Blood glucose  Blood lipid
基金项目:浙江省医药卫生科技计划项目(2019RC269)
作者单位
徐学文 吴向平 马 宏 翁金丽 胡长舟 宁波市康宁医院精神科浙江宁波 315000 
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中文摘要:
      目的 探讨3 种抗精神病药物对精神分裂症患者血糖指标、血脂指标的影响。方法 选取2018 年1 月至2019 年12 月我院收治的精神分裂症患者共120 例进行分组研究,根据使用药物的不同分为奥氮平组(A 组)、利培酮组(B 组)和阿立哌唑口崩片组(C 组),每组各40 例,分别口服对应药物治疗,治疗周期1 个月。于治疗前后分别检测入组患者的空腹血糖、餐后2 h 血糖、总胆固醇和三酰甘油并统计分析。结果 治疗前后B、C 两组各项指标检测结果相比较,差异均无统计学意义(P>0.05);治疗后A 组空腹血糖(FBG)、餐后2 h 血糖(2 hPBG)、三酰甘油(TG)指标检测结果均较治疗前显著升高,且显著高于治疗后的B、C 两组,差异有统计学意义(P<0.05)。结论 抗精神病药物用于精神分裂症患者的治疗时,利培酮和阿立哌唑口崩片对糖脂代谢影响较小,奥氮平可显著升高血糖、血脂水平,临床应用中应引起重视。
英文摘要:
      Objective To investigate the impacts of three antipsychotics on the indexes of blood glucose and blood lipid in schizophrenic patients.Methods A total of 120 schizophrenic patients admitted to our hospital from January 2018 to December 2019 were selected and divided into the olanzapine group(group A,n=40),the risperidone group (group B,n=40) and the aripiprazole orally disintegrating tablets group (group C,n=40) according to the different drugs used.Corresponding drugs were administrated orally to patients for one month.Before and after treatment,fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PBG),total cholesterol and triglyceride (TG) levels were detected and statistically analyzed.Results There was no statistically significant difference in test results of various indexes between group B and group C before and after treatment (P>0.05).After treatment,all indexes detection results of FBG,2 hPBG and TG in group A were raised more significantly than those before treatment,which were higher than those in the group B and group C after treatment,with significant difference(P<0.05).Conclusion When antipsychotic drugs are applied in the treatment of schizophrenia,the risperidone and aripiprazole orally disintegrating tablets have little impact on glucose and lipid metabolisms,while olanzapine can significantly raise blood glucose and blood lipid levels,which should be paid attention to in clinical application.
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