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赵 东.高通量血液透析治疗终末期肾病的效果及对心功能的影响[J].中国现代医生,2021,59(11):44-47
高通量血液透析治疗终末期肾病的效果及对心功能的影响
Effect of high-flux hemodialysis on end-stage renal disease and its influence on cardiac function
  
DOI:
中文关键词:  高通量血液透析  终末期肾病  心功能  大分子血清毒素
英文关键词:High-flux hemodialysis  End-stage renal disease  Heart function  Macromolecular toxin
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作者单位
赵 东 湖北省麻城市人民医院肾病内科湖北麻城 438300 
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中文摘要:
      目的 探讨高通量血液透析在终末期肾病(ESRD)中的应用效果。方法 选择2018 年2 月至2020 年2 月在我院行血液透析治疗的80 例ESRD 患者进行回顾性分析,按照治疗方式的不同分为对照组与观察组,每组各40 例,其中对照组患者采用常规血液透析治疗,观察组患者则采用高通量血液透析治疗,对比两组患者治疗前后的血清毒素水平、炎症因子水平以及心功能指标。结果 观察组在治疗后的β2微球蛋白(β2-MG)及甲状旁腺激素(PTH)指标明显低于对照组,差异有统计学意义(P<0.05);且治疗后观察组的白介素-6(IL-6)、白介素-18(IL-18)、肿瘤坏死因子(TNF-α)水平也显著低于对照组,差异有统计学意义(P<0.05);此外,治疗后观察组的每搏输出量(SV)、左心室射血分数(LVEF)均明显高于对照组,差异有统计学意义(P<0.05),而舒张期左室内径(LVEDD)及收缩期左室内径(LVESD)则明显低于对照组,差异有统计学意义(P<0.05)。结论 高通量血液透析对ESRD 患者炎症反应及心肌功能的改善均具有显著的应用效果。
英文摘要:
      Objective To explore the application effect of high-flux hemodialysis in end-stage renal disease (ESRD).Methods A total of 80 patients with ESRD who underwent hemodialysis in our hospital from February 2018 to February 2020 were analyzed retrospectively.According to different treatment methods,they were divided into the control group and the observation group,with 40 cases in each group.Patients in the control group were treated with routine hemodialysis,while patients in the observation group were treated with high-flux hemodialysis.The levels of serum toxins,inflammatory factors and cardiac function indexes were compared between the two groups before and after treatment.Results After treatment,β2-microglobulin (β2-MG) and parathyroid hormone(PTH) in the observation group were significantly lower than those in the control group,with significant difference (P<0.05).The levels of interleukin-6(IL-6),interleukin-18(IL-18) and tumor necrosis factor (TNF-α) in the observation group after treatment were also significantly lower than those in the control group,with significant difference (P<0.05).In addition,the stroke volume (SV)and left ventricular ejection fraction(LVEF) in the observation group after treatment were significantly higher than those in the control group,with significant difference (P<0.05),while the diastolic left ventricular diameter (LVEDD) and systolic left ventricular diameter (LVESD) in the observation group were significantly lower than those in the control group with significant difference (P<0.05).Conclusion High-flux hemodialysis has a significant application effect on the improvement of inflammatory reaction and myocardial function in ESRD patients.
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