| Objective To investigate the imaging characteristics of prenatal ultrasound and magnetic resonance imaging of fetal tuberous sclerosis.Methods The cases of fetal heart tumors and intracranial nodules detected by prenatal ultrasound detection from January 2015 to March 2020 were selected as the research objects.The location,size,number,and echo characteristics of the heart tumors were observed.The characteristic analysis was performed combined with the results of MRI and genetic testing.Results A total of 69 cases of cardiac tumors were found in 183 736 cases of the fetal heart by prenatal ultrasound screening,with an incidence of 0.38‰(69/183 736).The tumors appeared as round-shaped solid hyperechoic nodules,which occurred in the ventricle,atria,ventricular septum and outflow tract.Among 69 cases of fetal heart tumors,30 cases underwent fetal brain MRI,17 cases were positive,and 13 cases were negative;7 cases were tested for TSC gene locus,6 cases were positive,and 1 case was negative.Among them,13 cases underwent fetal cardiac ultrasound follow-up,12 cases had enlarged tumors with 4 cases increased,and 1 case remained the same in size and number.A total of 20 cases of TSC were finally confirmed clinically,and the incidence was 0.11‰ (20/183 736).Conclusion The size and number of fetal heart tumors change with the increase of gestational age.The larger the tumor volume and the number,the greater the possibility of the final diagnosis of tuberous sclerosis and the worse the prognosis.Prenatal ultrasound follow-up observation of the imaging characteristics of cardiac rhabdomyomas,combined with magnetic resonance examination and genetic testing,can provide help for the clinical diagnosis of tuberous sclerosis in a timely manner. |
