| 吴玲芳1 尉理梁2 李永兴1 陶学芳1▲.慢性阻塞性肺疾病急性发作患者呼出气冷凝液炎症因子检测对预后的评估价值[J].中国现代医生,2021,59(6):53-56 |
| 慢性阻塞性肺疾病急性发作患者呼出气冷凝液炎症因子检测对预后的评估价值 |
| Value of the detection of inflammatory factors in exhaled breath condensate of the patients with acute attacks of chronic obstructive pulmonary disease for the prognostic assessment |
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| 中文关键词: 慢性阻塞性肺疾病 急性发作 呼出气冷凝液 炎症因子 预后评估 |
| 英文关键词:Chronic obstructive pulmonary disease Acute attacks Exhaled breath condensate Inflammatory factors Prognostic assessment |
| 基金项目:浙江省医药卫生科技计划项目（2016KYA181）；浙江省绍兴市卫生计生委科技计划项目（2017QN007） |
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| 中文摘要: |
| 目的 探讨慢性阻塞性肺疾病急性发作患者呼出气冷凝液炎症因子检测对患者预后的指导价值。方法 选择2018 年7 月至2019 年10 月本院收治的慢性阻塞性肺疾病急性发作患者40 例，搜集所有患者的冷凝液，比较治疗前后机体氧代谢指标及肺功能指标，统计治疗前后炎症相关因子水平，及治疗前、治疗后3 d、7 d 炎症因子变化趋势，并分析超敏－C 反应蛋白（hs－CRP）水平与氧摄取率及第1 秒用力肺活量（FEV1）的相关性。结果 治疗后机体氧摄取率高于治疗前（P<0.05），动脉血氧含量高于治疗前（P<0.05），治疗后FEV1高于治疗前（P<0.05），1 s 用力呼气容积/用力肺活量（FEV1/FVC）水平大于治疗前（P<0.05），治疗后hs-CRP 及白细胞介素－1（IL－1）、肿瘤坏死因子－α（TNF－α）水平均显著低于治疗前（P＜0.05），随着时间的推移，患者炎症因子hs-CRP 水平、IL-1 水平及TNF-α 水平均呈下降趋势（P<0.05），hs-CRP 水平与氧摄取率及FEV1值呈负相关。结论 慢性阻塞性肺疾病急性发作者行呼出气冷凝液检测，可通过冷凝液中炎症因子水平变化对患者预后进行预测。 |
| 英文摘要: |
| Objective To explore the guiding value of the detection of inflammatory factors in exhaled breath condensate(EBC) of the patients with acute attacks of chronic obstructive pulmonary disease (COPD) for the prognosis of the patients.Methods A total of 40 patients with acute attacks of COPD admitted to and treated in our hospital from July 2018 to October 2019 were selected.EBC of each of the selected patients was collected;the indexes of oxygen metabolism of the whole body and pulmonary function parameters before and after treatment were compared;the levels of inflammation-related factors before and after treatment and the changing trend of inflammatory factors before,3 d and 7 d after treatment were counted;the correlation between the level of high sensitivity C-reactive protein(hs-CRP) and the extraction rate of oxygen (ERO2) and that between the level of hs-CRP and the forced expiratory volume in the first second (FEV1) were analyzed.Results After treatment,the ERO2of the whole body was higher than that before treatment(P<0.05),and the oxygen content of arterial blood(CaO2) was higher than that before treatment (P<0.05).After treatment,the FEV1level was higher than that before treatment (P<0.05),and the level of the forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) was higher than that before treatment(P<0.05).After treatment,the levels of hs-CRP,interleukin-1(IL-1),tumor necrosis factor-α (TNF-α) were all significantly lower than those before treatment(P<0.05).With time,the levels of hs-CRP,IL-1 and TNF-α of inflammatory factors in the patients showed a downward trend (P<0.05).The level of hs-CRP was negatively correlated with ERO2and the FEV1value.Conclusion The detection of the changes in the levels of inflammatory factors in the EBC of the patients with acute attacks of COPD can help to predict the prognosis of the patients. |
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