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徐 昕 朱珉之▲.血清免疫学检测在原发性胆汁性肝硬化诊断中的临床意义[J].中国现代医生,2021,59(4):119-121
血清免疫学检测在原发性胆汁性肝硬化诊断中的临床意义
Clinical significance of serum immunological detection in the diagnosis of Primary biliary cirrhosis
  
DOI:
中文关键词:  原发性胆汁性肝硬化  免疫球蛋白  肝功能  肝纤四项
英文关键词:Primary biliary cirrhosis  Immunoglobulin  Hepatic function  Four indexes of hepatic fibrosis
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作者单位
徐 昕 朱珉之▲ 江苏省常州市第三人民医院检验科江苏常州 213000 
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中文摘要:
      目的探讨肝脏免疫学血清检测在原发性胆汁性肝硬化诊断中的临床意义。方法 按照不同疾病分类,选取2017 年6 月至2019 年7 月我院收治的40 例PBC 患者为研究组,另选择慢性病毒性肝炎40 例为对照组,所选患者均做血清免疫学及肝功能检测,并对所选患者的肝纤四项、血清免疫球蛋白等临床意义进行分析。结果 研究组PBC 患者的平均年龄、性别及并发症与对照组比较,差异无统计学意义(P>0.05)。经血清免疫学原发性胆汁性肝硬化及肝功能指标情况分析,研究组的ALT、IgM、Ⅳ-c、HA、PCⅢ明显高于对照组,差异有统计学意义(P<0.05);而AST、IgA、IgG、LN 两组比较,差异无统计学意义(P>0.05)。结论探讨肝脏免疫学血清检测在PBC鉴别诊断中的临床意义,对患者早期风险评估及预后诊断有着重要的临床参考价值,值得进一步推广。
英文摘要:
      Objective To explore the clinical significance of serum hepatic immunological detection in the diagnosis of primary biliary cirrhosis (PBC).Methods Patients with PBC admitted to our hospital from June 2017 to July 2019 were selected as the study group (n=40),while patients with chronic viral hepatitis were selected as the control group(n=40)according to the different disease classifications.Serum immunological and hepatic function detection were performed in all selected patients,and the clinical significance of four indexes of hepatic fibrosis and serum immunoglobulin,etc.were analyzed.Results The average age,gender and complications of PBC patients in the study group were not significantly different from those in the control group,and none of the differences were statistically significant(P>0.05).After the patients′serum immunological detections were performed and the hepatic function indexes were analyzed,ALT,IgM,Ⅳ-c,HA and PCⅢin the study group were significantly higher than those in the control group,and the differences were all statistically significant(P<0.05).However,there was no significant differences in AST,IgA,IgG and LN between the two groups.Meanwhile,the differences were not statistically significant(P>0.05).Conclusion The investigation of the clinical significance of serum hepatic immunological detection in differential diagnosis of PBC,which has vital clinical reference value for early risk assessment and prognosis diagnosis of patients and is worthy of further promotion.
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