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刘 颖1 朱 永2.右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响[J].中国现代医生,2021,59(4):111-113+118
右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响
Efficacy of dexzopiclone in the treatment of insomnia and its effects on patients′ thyroid hormone levels
  
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中文关键词:  右佐匹克隆  失眠症  甲状腺激素  三碘甲腺原氨酸  甲状腺素  促甲状腺激素
英文关键词:Dexzopiclone  Insomnia  Thyroid hormones  Triiodothyronine  Thyroxine  Thyroid stimulating hormone
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刘 颖1 朱 永2 1.黑龙江省佳木斯精神病人福利院住院处药局黑龙江佳木斯 1540022.黑龙江省佳木斯精神病人福利院六病区黑龙江佳木斯 154002 
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中文摘要:
      目的探讨右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响。方法 选取2019 年1—12 月在我院诊断治疗的失眠症患者60 例为研究对象,随机分为观察组与对照组,每组各30 例。观察组采用右佐匹克隆治疗,对照组采用艾司唑仑治疗,比较两组治疗前后PSQI、T3、T4、TSH 水平及临床疗效。结果 治疗后两组PSQI 得分均低于治疗前,差异有统计学意义(P<0.05);治疗后观察组PSQI 得分显著低于对照组,差异有统计学意义(P<0.05)。治疗后两组T3、T4 均较治疗前显著下降,差异有统计学意义(P<0.05);治疗后观察组T3、T4 均显著低于对照组,差异有统计学意义(P<0.05);两组治疗前后TSH 比较,差异均无统计学意义(P>0.05)。观察组痊愈率为50.00%,高于对照组的16.67%,差异有统计学意义(P<0.05)。观察组总有效率为96.67%,高于对照组的83.33%,差异有统计学意义(P<0.05)。结论右佐匹克隆治疗失眠症具有较好的临床疗效,并且可降低甲状腺激素水平,有利于病情控制。
英文摘要:
      Objective To investigate the efficacy of dexzopiclone in the treatment of insomnia and its effects on the level of patients′ thyroid hormones.Methods A total of 60 patients with insomnia who were diagnosed and treated in our hospital from January to December 2019 were selected as the study subjects,and were randomly divided into an observation group and a control group,with 30 cases in each group.The observation group was given dexzopiclone for treatment,and the control group was given estazolam for treatment.The PSQI,T3,T4,TSH levels and clinical efficacy were compared between the two groups before and after treatment.Results The PSQI scores in both groups after treatment were lower than those before treatment,and the difference was statistically significant(P<0.05);after treatment,the PSQI score in the observation group was significantly lower than that in the control group,and the difference was statistically significant (P<0.05).After treatment,T3 and T4 in both groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05);after treatment,T3 and T4 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05);The differences of TSH in the two groups before and after treatment were not statistically significant(P>0.05).The recovery rate in the observation group was 50.00%,which was higher than that 16.67% in the control group,the difference was statistically significant (P<0.05).The total effective rate in the observation group was 96.67%,which was higher than that of 83.33% in the control group.However,the difference was statistically significant(P<0.05).Conclusion Dexzopiclone has a favorable clinical effect in the treatment of insomnia,and can reduce the level of thyroid hormones,which is beneficial to the control of disease conditions.
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