中国现代医生杂志欢迎您.   今天是:          
李树武 李晓锋▲ 寇广海.右美托咪定复合酮咯酸氨丁三醇在腹腔镜结直肠癌术后静脉自控镇痛中的应用及安全性分析[J].中国现代医生,2021,59(4):106-110
右美托咪定复合酮咯酸氨丁三醇在腹腔镜结直肠癌术后静脉自控镇痛中的应用及安全性分析
Application and safety analysis of dexmedetomidine combined with ketorolac tromethamine in patient-controlled intravenous analgesia after laparoscopic colorectal cancer surgery
  
DOI:
中文关键词:  右美托咪定  酮咯酸氨丁三醇  腹腔镜  结直肠癌  静脉自控镇痛  安全性
英文关键词:Dexmedetomidine  Ketorolac tromethamine  Laparoscopy  Colorectal cancer  Patient-controlled intravenous analgesia  Safety
基金项目:
作者单位
李树武 李晓锋▲ 寇广海 辽宁省盘锦辽油宝石花医院麻醉科辽宁盘锦 124000 
摘要点击次数: 54
全文下载次数: 117
中文摘要:
      目的探讨右美托咪定复合酮咯酸氨丁三醇(Ket)在结直肠癌(CRC)腹腔镜术后静脉自控镇痛中的应用及安全性。方法 选取辽宁省盘锦辽油宝石花医院于2016 年1 月至2018 年1 月收治的CRC 患者107 例进行前瞻性研究,以RNTM 将其分成A、B、C组,各37 例、35 例和35 例,其中A组单纯予以右美托咪定治疗,B组单纯予以酮咯酸氨丁三醇治疗,C组则联合(Dex 联合Ket)治疗,且所有A、B、C组的手术方法均相同,即为腹腔镜CRC 术,比较三组患者的自控镇痛效果及其安全性。结果 (1)C组术后T1、T2、T3、T4、T5时的VAS(静息痛、活动痛)评分均低于A、B组,差异有统计学意义(P<0.05),而A、B组术后T1~T5时的以上两项疼痛评分指标均无显著差异(P>0.05)。(2)三组术后48 h 内的镇痛、药物及排气时间差异有统计学意义(P<0.05),且C组术后48 h 内的有效按压次数、镇痛急救次数、舒芬太尼使用总量、术后肛门首次排气时间与A、B组相比更低(P<0.05)。(3)A组不良反应发生率为32.43%,B组为37.14%,C组为8.57%,三组不良反应发生率比较,差异有统计学意义(P<0.05),且C组不良反应发生率显著低于A、B组,差异有统计学意义(P<0.05)。结论在CRC 患者的临床治疗中科学、合理地予以Dex 复合Ket 治疗能有效地改善患者腹腔镜术后PCIA 效果,安全性较好,可在临床医学中适当推广与普及,为CRC 及相关并发症患者造福。
英文摘要:
      Objective To explore the application and safety of dexmedetomidine combined with ketorolac tromethamine in patient-controlled intravenous analgesia after laparoscopic surgery for colorectal cancer (CRC).Methods A total of 107 CRC patients in Panjin Liaoyou Baoshihua Hospital from January 2016 to January 2018 were selected for prospective study.They were divided into group A(n=37),group B(n=35) and group C(n=37) by RNTM.Group A was treated with dexmedetomidine,group B was treated with ketorolac tromethamine,and group C was treated with dexmedetomidine combined with ketorolac tromethamine.All groups underwent the same operation-laparoscopic CRC.The efficacy and safety of patient-controlled analgesia were compared among the three groups.Results (1)VAS(rest pain and movement pain) score and RSS score of group C at T1,T2,T3,T4and T5after operation were lower than those of group A and B,with statistically significant difference(P<0.05).There was no significant difference between group A and group B in the above two pain scoring indexes from T1to T5after operation(P>0.05).(2)There were significant differences in analgesia,medication and exhaust time among the three groups within 48 hours after operation(P<0.05),and the effective pressing times,analgesia times,total amount of sufentanil used and first exhaust time of anus after operation in group C were lower than those in group A and group B(P<0.05).(3) The adverse reaction rates of group A,group B and group C were 32.43%,37.14% and 8.57%,respectively.There was significant difference among the three groups(P<0.05),and the adverse reaction rates of group C were significantly lower than those of groups A and B(P<0.05).Conclusion Dexmedetomidine combined with ketorolac tromethamine can effectively improve the PCIA effect of CRC patients after laparoscopic surgery,with high safety.Thus,this combined therapy can be properly promoted and popularized in clinic for the benefit of CRC patients and related complications.
查看全文  查看/发表评论  下载PDF阅读器
关闭
    • 关键词 :
    • 中国医生
    • 中国现代医生
    • 中国临床医生
    • 中国医师
    • 主任医师
    • 中国医学
    • 中华医学
    • 中国医院
    • 中国医药
    • 中国医疗
    • 现代医生
    • 现代医学
    • 现代医药
    • 现代医院
    • 现代药物
    • 现代护理
    • 现代临床
    • 医学杂志
    • 药学杂志
    • 医药杂志
    • 医生杂志
    • 医师杂志
    • 医疗杂志
    • 医药期刊
    • 医学期刊
    • 医药卫生期刊
    • 医药论文
    • 医学论文
    • 科研论文
    • 职称论文
    function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=DCA5CABA83612A941DEC9A1CB6804E93CEACD85ABA1175039E9E2E109FAE6BAF486C5FDB8FD1C3FB5E1D5C72D2602DAE8A30AAB58D3A077D7C42F39811526865A3DFA2E1884281FB6A33519B552AEC97ED123174FF5CBD044E41AE98BBABE82DB034912F04729560A6A12EE9FFB2CBFFA18BF9EF1BDE64A34B98EEC0C9BD6456305586A2BDF9FC4CA50C6C84F89980F272F3A1136BB1871531521203BF6D1FE6421974208EE1B0F948EA0FE5E632F11D1E299F8312D3C356&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=BB33F1C95224820A&jid=8EDAEC11C165015425CEEA15366CB0A7&yid=9475FABC7A03F4AB&aid=&vid=&iid=E158A972A605785F&sid=F24949CFDB502409&eid=4DB1E72614E68564&fileno=2021956&flag=1&is_more=0">