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宋丽丽.三维适形放疗同步吉非替尼化疗治疗局部晚期肺腺癌的疗效[J].中国现代医生,2021,59(4):72-74+78
三维适形放疗同步吉非替尼化疗治疗局部晚期肺腺癌的疗效
The efficacy of three-dimensional conformal radiotherapy combined with gefitinib chemotherapy for locally advanced lung adenocarcinoma
  
DOI:
中文关键词:  肺腺癌  吉非替尼化疗  三维适形放疗  细胞因子水平  不良反应
英文关键词:Lung adenocarcinoma  Gefitinib chemotherapy  Three-dimensional conformal radiotherapy  Cytokine level  Adverse reactions
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作者单位
宋丽丽 黑龙江省佳木斯市肿瘤医院肿瘤五科黑龙江佳木斯 154002 
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中文摘要:
      目的探讨局部晚期肺腺癌应用三维适形放疗同步吉非替尼化疗治疗的效果。方法 选择2019 年1 月至2020 年1 月我院收治的晚期肺腺癌患者76 例,按照随机数字表法分为两组,每组各38 例。对照组实施三维适形放疗,观察组在此基础上同步吉非替尼化疗,比较两组的治疗效果、细胞因子水平[白细胞介素2(IL-2)、肿瘤坏死因子-α(TNF-α)、集落刺激因子(CSF)]及不良反应发生情况。结果 观察组疾病控制率(DCR)、总有效率(RR)分别为97.37%、81.58%,均高于对照组的78.95%、52.63%,差异有统计学意义(P<0.05);与对照组相比,观察组治疗2 个月后IL-2、CSF 水平较高,TNF-α 水平较低,且两组治疗后均优于治疗前,差异有统计学意义(P<0.05);观察组不良反应总发生率为21.05%,低于对照组的34.21%,但差异无统计学意义(P>0.05)。结论局部晚期肺腺癌应用三维适形放疗同步吉非替尼化疗治疗的效果较好,安全性较高。
英文摘要:
      Objective To investigate the efficacy of three-dimensional conformal radiotherapy combined with gefitinib chemotherapy for locally advanced lung adenocarcinoma.Methods A total of 76 patients with advanced lung adenocarcinoma admitted to our hospital from January 2019 to January 2020 were selected and divided into the observation group(n=38) and the control group (n=38) according to the random number table method.The control group was treated with three-dimensional conformal radiotherapy,while the observation group was treated with gefitinib chemotherapy on the above basis simultaneously.The therapeutic efficacy,cytokine levels (interleukin-2[IL-2],tumor necrosis factor-α[TNF-α],colony stimulating factor [CSF]) and adverse reactions (ADRs) were compared between the two groups.Results The disease control rate (DCR) and overall response rate (RR) in the observation group were 97.37% and 81.58%,which were higher than 78.95% and 52.63% in the control group respectively,with statistically significant differences(P<0.05).Compared with the control group,the levels of IL-2 and CSF in the observation group were higher and the level of TNF-α was lower at 2 months after treatment,and both groups were better than those before treatment,with statistically significant differences(P<0.05).The total incidence of ADRs in the observation group was 21.05%,which was slightly lower than 34.21% in the control group,but the differences were not statistically significant(P>0.05).Conclusion Three-dimensional conformal radiotherapy combined with gefitinib chemotherapy is safe and effective for locally advanced lung adenocarcinoma.
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