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黄晓莉 叶津津 唐月莲.Omega-3脂肪酸在预防乳腺癌化疗患者口腔黏膜炎中的效果[J].中国现代医生,2021,59(4):26-29
Omega-3脂肪酸在预防乳腺癌化疗患者口腔黏膜炎中的效果
The effect of Omega-3 fatty acid in preventing oral mucositis in patients with breast cancer chemotherapy
  
DOI:
中文关键词:  Omega-3 脂肪酸  乳腺癌  口腔黏膜炎  化疗
英文关键词:Omega-3 fatty acids  Breast cancer  Oral mucositis  Chemotherapy
基金项目:浙江省中医药科技计划项目(2020ZB243)
作者单位
黄晓莉 叶津津 唐月莲 浙江省湖州市中医院肿瘤科浙江湖州 313000 
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中文摘要:
      目的观察Omega-3 脂肪酸在预防乳腺癌化疗患者口腔黏膜炎中的效果。方法 选取2018 年3 月至2019 年10 月我院住院乳腺癌化疗患者120 例为研究对象,按照随机数字表法将其随机分为对照组和试验组,每组各60 例,对照组患者给予醋酸氯已定常规口腔治疗,试验组在对照组的基础上加服Omega-3 脂肪酸。并对两组患者口腔真菌感染、牙周健康和口腔黏膜炎严重程度状况进行比较。结果 试验组患者的真菌感染率为5.00%(3/60),明显低于对照组的16.67%(10/60),差异有统计学意义(χ2=4.227,P<0.05);试验组患者的菌斑指数为(1.32±0.25)、牙龈指数为(1.27±0.22),明显低于对照组的(2.41±0.33)、(2.19±0.39),差异均有统计学意义(P<0.05);试验组患者的口腔黏膜炎分级0 级比例为81.67%(49/60),明显高于对照组的41.67%(28/60),差异有统计学意义(P<0.05),试验组Ⅰ~Ⅱ级、Ⅲ~Ⅳ级比例为11.67%(7/60)、6.67%(4/60),均明显低于对照组的28.33%(17/60)、25.00%(15/60),差异均有统计学意义(P<0.05)。结论Omega-3 脂肪酸在预防乳腺癌化疗患者口腔黏膜炎中具有较好的预防和治疗效果,值得临床推广应用。
英文摘要:
      Objective To observe the effect of Omega-3 fatty acid in preventing oral mucositis in patients with breast cancer chemotherapy.Methods A total of 120 patients with breast cancer chemotherapy who were hospitalized in our hospital from March 2018 to October 2019 were selected as the research object,and they were randomly divided into a control group and an experimental group according to the random number table method,with 60 cases in each group.Patients in the control group were given regular oral treatment with chlorhexidine acetate.The experimental group added Omega-3 fatty acid on the basis of the treatment in control group.The oral fungal infection,periodontal health,and oral mucositis severity were compared between the two groups.Results The fungal infection rate of patients in the experimental group was 5.00%(3/60),which was significantly lower than 16.67% (10/60) of the patients in the control group,and the difference was statistically significant(χ2=4.227,P<0.05).The plaque index (1.32±0.25) and gingival index(1.27±0.22) were significantly lower than those in the control group(2.41±0.33)and (2.19±0.39),and the differences were statistically significant(P<0.05).The proportion of mucositis grade 0 was 81.67% (49/60) in the experimental group,which was significantly higher than 41.67% (28/60) in the control group (P<0.05),and the ratio of grades Ⅰto Ⅱ,ⅢtoⅣwas 11.67% (7/60),6.67% (4/60) in the experimental group,which was significantly lower than 28.33% (17/60) and 25.00% (15/60) in the control group,and the difference was statistically significant(P<0.05).Conclusion Omega-3 fatty acid has good preventive and therapeutic effects in the prevention of oral mucositis in breast cancer chemotherapy patients,and it is worthy of clinical application.
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