中国现代医生杂志欢迎您.   今天是:          
刘玲佩1 陈光明1 王华斌2▲.ACR联合尿β2-MG检测在妊娠合并糖尿病早期肾损害中的诊断价值[J].中国现代医生,2021,59(4):13-17
ACR联合尿β2-MG检测在妊娠合并糖尿病早期肾损害中的诊断价值
The value of joint detection of ACR and urine β2-MG in the diagnosis of early renal damage in pregnancy complicated by diabetes mellitus
  
DOI:
中文关键词:  妊娠合并糖尿病  尿微量白蛋白与尿肌酐比值  尿β2-微球蛋白  早期肾损害  临床诊断
英文关键词:Pregnancy complicated by diabetes mellitus  Urine microalbumin/creatinine ratio  Urine β2-microglobumin  Early renal damage  Clinical diagnosis
基金项目:浙江省科技计划项目(2017C33206)
作者单位
刘玲佩1 陈光明1 王华斌2▲ 1.浙江大学医学院附属金华医院全科医学浙江金华 3210002.浙江大学医学院附属金华医院中心实验室浙江金华321000 
摘要点击次数: 63
全文下载次数: 125
中文摘要:
      目的探究尿微量白蛋白与尿肌酐比值(ACR)联合尿β2-微球蛋白(β2-MG)检测对妊娠合并糖尿病患者早期肾损害的临床诊断效果。方法 随机纳入2019 年1—12 月我院接收进行定期孕检的产妇150 例。其中33 例诊断为孕前糖尿病(PGDM)的产妇纳入PGDM组、70 例妊娠期糖尿病(GDM)产妇纳入GDM组、47 例健康产妇纳入对照组。检测产妇血清糖化血红蛋白(HbA1c)、ACR、尿β2-MG、血肌酐(Scr)、血尿素氮(BUN)水平,并比较各指标检测阳性率。结果 GDM组、PGDM组尿β2-MG、ACR、Scr 及HbA1c 水平高于对照组(P<0.05),GDM组、PGDM组BUN 水平与对照组比较,差异无统计学意义(P>0.05)。PGDM组尿β2-MG、ACR 及HbA1c 水平高于GDM组(P<0.05);PGDM组Scr、BUN 水平与GDM组比较,差异无统计学意义(P>0.05);PGDM组、GDM组尿β2-MG、ACR 检测阳性率高于对照组(P<0.05);PGDM组、GDM组BUN 及Scr 检测阳性率与对照组比较,差异无统计学意义(P>0.05)。PGDM组ACR 及尿β2-MG 检测阳性率高于GDM组(P<0.05),PGDM组BUN 及Scr 检测阳性率与GDM组比较,差异无统计学意义(P>0.05)。GDM组内B 亚组ACR、尿β2-MG、ACR 联合尿β2-MG 检测阳性率高于A 亚组(P<0.05),A、B 亚组患者BUN 及Scr 检测阳性率比较,差异无统计学意义(P>0.05)。结论临床针对GDM 患者可结合HbA1c 检测情况,进行ACR、尿β2-MG 指标水平联合检测判断其早期肾损害及肾损害程度,及早接受治疗干预,以防止并延缓妊娠并糖尿病患者肾损害症状发展至不可逆期,该检测方法具有临床应用价值。
英文摘要:
      Objective To explore the effect of the joint detection of urine microalbumin/creatinine ratio(ACR) and urine β2-microglobumin (β2-MG) on clinical diagnosis of early renal damage in pregnant women with diabetes mellitus(DM).Methods A total of 150 parturients who received regular pregnancy tests in our hospital from January to December 2019 were randomly selected.Among these parturients,33 cases diagnosed with pregestational diabetes mellitus(PGDM) were included in the PGDM group,70 with gestational diabetes mellitus(GDM) were included in the GDM group,and 47 healthy parturients were included in the control group.The levels of the indexes of serum glycosylated hemoglobin(HbA1c),ACR,urine β2-MG,blood creatinine(Scr) and blood urea nitrogen (BUN) were detected,and the positive rate of each index was compared.Results The levels of the urine β2-MG,ACR,Scr and HbA1c of the patients in the GDM group and PGDM group were significantly higher than those in the control group(P<0.05),and the levels of BUN were not significantly different from that in the control group (P>0.05).The levels of urine β2-MG,Scr ACR and HbA1c of the patients in the PGDM group were significantly higher than those in the GDM group(P<0.05).The levels Scr and BUN of the patients in the PGDM group were not significantly different from those in the GDM group(P>0.05).The positive rates of the detection of urine β2-MG and ACR of the patients in the PGDM group and GDM group were significantly higher than those in the control group(P<0.05).The positive rates of the detection of BUN and Scr of the patients in the PGDM group and GDM group were not significantly different from those in the control group(P>0.05).The positive rates of the detection of ACR and urine β2-MG of the patients in the PGDM group were significantly higherthan those in the GDM group(P<0.05),and the positive rates of the detection of BUN and Scr were not significantly different from those in the GDM group(P>0.05).In GDM group,the positive rates of ACR,urine β2-MG and ACR combined with urine β2-MG in subgroup B were higher than those in subgroup A(P<0.05).There was no significant difference in the positive rates of BUN and Scr in subgroup A and B(P>0.05).Conclusion In clinical practice,as far as the patients with GDM are concerned,with reference to the result of the detection of HbA1c,a joint detection of the levels of the indexes of ACR and urine β2-MG can be conducted for judging their early renal damage and the extent of the damage,so that they could receive treatment intervention as early as possible to prevent the symptoms of renal damage in pregnant women with DM from developing to the irreversible stage and delay the development.The detection method has application value in clinical practice.
查看全文  查看/发表评论  下载PDF阅读器
关闭
    • 关键词 :
    • 中国医生
    • 中国现代医生
    • 中国临床医生
    • 中国医师
    • 主任医师
    • 中国医学
    • 中华医学
    • 中国医院
    • 中国医药
    • 中国医疗
    • 现代医生
    • 现代医学
    • 现代医药
    • 现代医院
    • 现代药物
    • 现代护理
    • 现代临床
    • 医学杂志
    • 药学杂志
    • 医药杂志
    • 医生杂志
    • 医师杂志
    • 医疗杂志
    • 医药期刊
    • 医学期刊
    • 医药卫生期刊
    • 医药论文
    • 医学论文
    • 科研论文
    • 职称论文
    function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=2CA206990F191D71127088555D5FBACC145D4F9EE6EC284F7F5CB5E709155E6D1F4DC34DF934CE20DBF8F714FBAE237AE4A5DFD9E2AC6E2F2FD95721AA636A73405C5840C6920DD1E3B2271873FA6299AE7008EC9CF760CB20B8EDC3F8B3A187EAFEE837F9C3C27E91107DEF6DBBB15A846D18E3FADF693BA943EA34655F78BB94E6DD20929C6E9C68C12A0BE1E21325&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=BB33F1C95224820A&jid=8EDAEC11C165015425CEEA15366CB0A7&yid=9475FABC7A03F4AB&aid=&vid=&iid=E158A972A605785F&sid=FC0714F8D2EB605D&eid=BCA2697F357F2001&fileno=2021932&flag=1&is_more=0">